Evidence map›Paper›PMID 37222811›Full record

ArticleJournal of cancer research and clinical oncology2023

The prognostic value of FAR and a novel FAR-CA125 score in resectable gastric signet ring cell carcinoma patients.

Yimin Shen, Yuanyuan Li, Zhou Wang, Wei Xu, Wenjie Wang, Xiao Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yimin ShenThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Yuanyuan LiThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Zhou WangThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Wei XuThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Wenjie WangDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China.
Xiao ChenDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China. chenxiaomd@126.com.
Lanzhou University · CNLanzhou University Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe fibrinogen to albumin ratio (FAR) is increasingly regarded as a potential biomarker for predicting prognosis in variety of malignant tumors, but not in gastric signet ring cell carcinoma (GSRC). This study seeks to examine the prognostic value of the FAR and explore a novel FAR-CA125 score (FCS) in resectable GSRC patients.

methodsA retrospective cohort was conducted including 330 GSRC patients who underwent curative resection. Kaplan-Meier (K-M) and Cox regression were used to analysis the prognostic value of FAR and FCS. And a predictive nomogram model was developed.

resultsThe optimal cut-off values for CA125 and FAR were 9.88 and 0.0697, respectively, according to the receiver operating characteristic curve (ROC). Th area under the ROC curve of FCS is higher than CA125 and FAR. 330 patients were grouped into three groups according to the FCS. High FCS was related to males, anemia, tumor size, TNM stage, lymph node metastasis, tumor invasion depth, SII, and pathological subtypes. K-M analysis showed that high FCS and FAR were associated with poor survival. In the multivariate analysis, FCS, TNM stage, and SII were independent prognostic factors for poor OS in resectable GSRC patients. And the predictive accuracy of clinical nomogram contained FCS was better than TNM stage.

conclusionThis study indicated that the FCS is a prognostic, and effective biomarker for patients with surgically resectable GSRC. Such developed FCS-based nomogram could be effective tools to assist the clinicians to determine the treatment strategy.

Indexed as

Carcinoma, Signet Ring CellStomach NeoplasmsBiomarkers, TumorHumansMalePrognosisRetrospective StudiesBiomarkers, TumorFCSGastric signet ring cell carcinomaInflammationPrognostic factor

Identifiers

PMID37222811
PMCPMC11798286
OpenAlexW4377939827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.