ArticleThe Journal of cell biology1986
270K microtubule-associated protein cross-reacting with anti-MAP2 IgG in the crayfish peripheral nerve axon.
Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology.Neural development · 2019Review
- Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Two distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation and longitudinal elongation of filaments.The Journal of cell biology · 1995Article
- KIF3A is a new microtubule-based anterograde motor in the nerve axon.The Journal of cell biology · 1994Article
- Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase.Molecular biology of the cell · 1994Article
- Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quail.Acta neuropathologica · 1991Article
- Effects of phosphorylation of the neurofilament L protein on filamentous structures.Cell regulation · 1990Article
- Conformational change and localization of calpactin I complex involved in exocytosis as revealed by quick-freeze, deep-etch electron microscopy and immunocytochemistry.The Journal of cell biology · 1990Article
- A squid dynein isoform promotes axoplasmic vesicle translocation.The Journal of cell biology · 1989Article
- Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.The Journal of cell biology · 1989Article
- Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Tau proteins: the molecular structure and mode of binding on microtubules.The Journal of cell biology · 1988Article
- Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells.The Journal of cell biology · 1988Article
- Different structural states of a microtubule cross-linking molecule, captured by quick-freezing motile axostyles in protozoa.The Journal of cell biology · 1986Article
- Purification and characterization of a 190-kD microtubule-associated protein from bovine adrenal cortex.The Journal of cell biology · 1986Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAPs (microtubule-associated proteins) were isolated from crayfish walking leg nerves. A major MAP was identified as a high molecular weight protein (270K). This protein co-migrated with mammalian MAP2, stimulated the polymerization of rat brain tubulin into microtubules, and was heat resistant. Rotary shadowing revealed that the 270K MAP is a long thin flexible structure. It formed cross-bridges of fine strands, linking microtubules with each other in vitro. These strands resemble the cross-bridges between microtubules observed in the crayfish axon permeabilized with saponin and quick-frozen, deep-etched. Antibodies against mammalian MAP2 cross-reacted with this crayfish MAP and stained the axoplasm of the walking leg nerves. Thus MAPs, especially the 270K MAP, appear to be a major component of the cross-linking strands between microtubules observed in the crayfish axon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.