Evidence map›Paper›PMID 37222469›Full record

ArticleAmerican journal of epidemiology2023

Invited Commentary: The Winding Road to Identifying the Annual Rate of Tuberculosis Infection.

C Robert Horsburgh

Abstract readComment
PubMed Publisher
In one paragraph

Article in American journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Overlooked, dismissed, and downplayed: reversion ofEuropean respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  4. Schwalb and Houben Respond to "The Winding Road to ARTI".American journal of epidemiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

C Robert Horsburgh

Funding

Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)R01AI147316 · NIAID · BOSTON MEDICAL CENTER · PI JACOBSON, KAREN R · 2019 to 2023
$3.5M
6 · The paper itself

Abstract

Many persons with immunological tests indicating Mycobacterium tuberculosis infection, such as tuberculin skin tests or interferon-γ release assays, are at risk of progression to tuberculosis disease. Persons whose tests revert to negative may no longer be at such risk. Therefore, identifying the rate of test reversion, potentially indicating cure of M. tuberculosis infection, is an important area of investigation. In their accompanying article (Am J Epidemiol. 2023;192(12):1937-1943), Schwalb et al. extract data on test reversion from prechemotherapy literature and construct a model to predict the rate of reversion, and thus the likely cure of infection. Unfortunately, the incompleteness of the historical data and the use of imprecise definitions of test positivity and reversion lead to substantial misclassification and limit the usefulness of the model. Better definitions and improved tests will be needed in order to develop a clear picture of this aspect of the natural history of tuberculosis.

Indexed as

Latent TuberculosisMycobacterium tuberculosisTuberculosisHumansInterferon-gamma Release TestsTuberculin Testinterferon-γ release assayM. tuberculosis infectionMycobacterium tuberculosistuberculin skin testtuberculosis

Identifiers

PMID37222469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.