Evidence map›Paper›PMID 37222162›Full record

ReviewJournal of child psychology and psychiatry, and allied disciplines2023

Research Review: The internalizing paradox - youth anxiety and depression symptoms, psychotherapy outcomes, and implications for research and practice.

John R Weisz, Olivia M Fitzpatrick, Katherine E Venturo-Conerly, Ariel Sternberg, Joshua S Steinberg, Mei Yi Ng

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of child psychology and psychiatry, and allied disciplines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

John R WeiszDepartment of Psychology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-5560-6814
Olivia M FitzpatrickDepartment of Psychology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-8868-6702
Katherine E Venturo-ConerlyDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Ariel SternbergDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Joshua S SteinbergDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Mei Yi NgDepartment of Psychology, Florida International University, Miami, FL, USA.
Harvard University · USFlorida International University · US

Funding

Testing FIRST in Youth Outpatient PsychotherapyR01MH124965 · NIMH · HARVARD UNIVERSITY · PI BEARMAN, SARAH KATE KATE, WEISZ, JOHN RICHARD · 2021 to 2025
$4.3M
Identifying Person-Specific Drivers of Adolescent Depression via Idiographic Network Modeling of Active and Passive Smartphone DataR21MH126394 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI NG, MEI YI · 2021 to 2022
$422k
Clinician-Consumer Collaboration in Transdiagnostic, Modular Youth PsychotherapyF31MH127862 · NIMH · HARVARD UNIVERSITY · PI FITZPATRICK, OLIVIA MAE · 2021 to 2023
$111k
NIMH NIH HHS 1R21MH126394-01NIMH NIH HHS F31 MH127862NIMH NIH HHS R01 MH124965NIMH NIH HHS R21 MH126394TWCF
6 · The paper itself

Abstract

backgroundYouth anxiety and depression have long been combined within the empirically derived internalizing syndrome. The two conditions show substantial comorbidity, symptom co-occurrence, and overlap in treatment procedures, but paradoxically diverge in psychotherapy outcomes: strong, positive effects for anxiety and weak effects for depression.

methodsDrawing on recent research, we examine candidate explanations for this paradox to help identify strategies for addressing it by improving outcomes for youth depression.

resultsCandidate explanations include that youth depression, compared with youth anxiety, has more varied comorbidities and more heterogeneous symptom combinations, has greater uncertainty regarding mediators and mechanisms of change, is treated with more complex and potentially confusing protocols, and has characteristics that may impede client engagement. Candidate strategies for shrinking the psychotherapy effectiveness gap include personalizing through transdiagnostic modular treatment, simplifying therapy by focusing on empirically supported principles of change, developing effective strategies for engaging family members as intervention allies, using shared decision-making to inform clinical decisions and boost client engagement, capitalizing on youth-friendly technological advances, and shortening and digitizing treatments to enhance their accessibility and appeal.

conclusionsRecent advances suggest explanations for the internalizing paradox, which in turn suggest strategies for shrinking the youth anxiety-depression psychotherapy outcome gap; these form an agenda for a promising new era of research.

Indexed as

AnxietyDepressionAdolescentAnxiety DisordersComorbidityHumansPsychotherapyadolescentsanxietyChildrendepressioninternalizingpsychotherapyyouth

Identifiers

PMID37222162
PMCPMC10667566
OpenAlexW4377940778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.