ArticleLangmuir : the ACS journal of surfaces and colloids2023
Antibodies Adsorbed to the Air-Water Interface Form Soft Glasses.
Article in Langmuir : the ACS journal of surfaces and colloids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Compression and Interpenetration of Ionic Microgels in Electrostatically Self-Assembled Clusters.ACS nano · 2026Article
- How to Successfully Navigate Flatland: A Tutorial on the Rheometry of Fluid-Fluid Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Predicting Agitation Stability of Monoclonal Antibodies during Developability Assessment.Molecular pharmaceutics · 2026Article
- Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient.Science translational medicine · 2025Article
- Air-Water Interfacial Adsorption of the Chaperone Protein DNAJB6b.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Mitigation Strategies against Antibody Aggregation Induced by Oleic Acid in Liquid Formulations.Molecular pharmaceutics · 2024Article
- Adsorption of monoclonal antibody fragments at the water-oil interface: A coarse-grained molecular dynamics study.APL bioengineering · 2024Article
- Mechanistic Insights into the Adsorption of Monoclonal Antibodies at the Water/Vapor Interface.Molecular pharmaceutics · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When monoclonal antibodies are exposed to an air-water interface, they form aggregates, which negatively impacts their performance. Until now, the detection and characterization of interfacial aggregation have been difficult. Here, we exploit the mechanical response imparted by interfacial adsorption by measuring the interfacial shear rheology of a model antibody, anti-streptavidin immunoglobulin-1 (AS-IgG1), at the air-water interface. Strong viscoelastic layers of AS-IgG1 form when the protein is adsorbed from the bulk solution. Creep experiments correlate the compliance of the interfacial protein layer with the subphase solution pH and bulk concentration. These, along with oscillatory strain amplitude and frequency sweeps, show that the viscoelastic behavior of the adsorbed layers is that of a soft glass with interfacial shear moduli on the order of 10
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Registered trials
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