Observational studyClinical endocrinology2023
The Association between Inflammation, Testosterone and SHBG in men: A cross-sectional Multi-Ethnic Study of Atherosclerosis.
Observational study in Clinical endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Gout, hyperuricemia, and male reproductive health: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Association between a novel nutritional-inflammatory index and testosterone levels: a cross-sectional study.Sexual medicine · 2026Article
- The Liver-Testis Axis: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- Low Testosterone in Men With Type 2 Diabetes: The Role of Estrogen Excess and Aromatase Activity.Clinical endocrinology · 2026Article
- Effect of Vitamin K Supplementation on Testosterone Production in a Rat Model of Late-Onset Hypogonadism.Foods (Basel, Switzerland) · 2026Article
- Differences in testosterone levels in perianal diseases: A comparative study of abscesses and fistulas.World journal of gastrointestinal surgery · 2026Article
- Metabolic Messengers: testosterone.Nature metabolism · 2026Review
- Revitalizing equine metabolism: how SHBG improves mitochondrial function and reduces inflammation.BMC veterinary research · 2025Article
- Current perspectives on the pathogenesis of cerebral atherosclerosis.Journal of inflammation (London, England) · 2025Review
- Breaking the metabolic-inflammatory vicious cycle in polycystic ovary syndrome: a comparative review of ketogenic and high-fat diets.Lipids in health and disease · 2025Review
- Association between circulatory immune cell to high-density lipoprotein cholesterol ratios and testosterone level in adult men: findings from NHANES 2011-2016.BMC endocrine disorders · 2025Article
- Association between the C-reactive protein-triglyceride glucose index and erectile dysfunction in US males: results from NHANES 2001-2004.International journal of impotence research · 2025Article
- The importance of ALPK1 kinase functionality as a potential biomarker for inflammatory diseases.Molecular biology reports · 2025Review
- Correlation between pan immune inflammation value and testosterone deficiency risk increase.Scientific reports · 2025Article
- Article
- Observational
- Association between C-reactive protein-triglyceride glucose index and testosterone levels among adult men: analyses of NHANES 2015-2016 data.Sexual medicine · 2025Article
- Negative association between 15 obesity- and lipid-related indices and testosterone in adult males: a population based cross-sectional study.Lipids in health and disease · 2025Article
- Impact of Obesity on Pubertal Timing and Male Fertility.Journal of clinical medicine · 2025Review
- Levels of Sex Hormones and Abdominal Muscle Composition in Men from The Multi-Ethnic Study of Atherosclerosis.Scientific reports · 2024Observational
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
contextEarlier studies have investigated the role of obesity-related inflammation and endogenous sex hormones in men. The role of interleukin-6 (IL-6) and C-reactive protein (CRP) with testosterone and sex hormone binding globulin (SHBG) levels in men is still debated.
objectiveTo investigate the independent association between levels of high sensitivity CRP (hsCRP) and IL-6 with endogenous sex hormones in men.
designCross-sectional observational study using data from the Multi-Ethnic Study of Atherosclerosis. PATIENTS OR OTHER
participantsA community-based sample of 3212 men aged 45-84 years was included. After exclusions, 3041 men remained for the analyses. MAIN OUTCOME MEASURE(S): Serum concentrations of testosterone, SHBG, hsCRP, IL-6, and sTNFR were measured from the baseline exam. Multivariable linear regressions were used to examine the association of inflammatory markers with sex hormones.
resultsAn inverse association was found between levels of hsCRP and levels of testosterone and SHBG, even after adjustment for confounders and IL-6 (Total Testosterone; B = -0.14, Bioavailable Testosterone; B = -0.06, and SHBG; B = -0.66). Similar results were found for IL-6, although a positive association was found for SHBG (B = 0.95). Notably, an inverse association was found for IL-6 with bioavailable testosterone in African Americans and Hispanic Americans aged 45-54 years. No associations were found for sTNFR and endogenous sex hormones.
conclusionOur results indicate that inflammatory markers have independent associations with levels of testosterone (total and bioavailable) and furthermore, appear to associate differently with SHBG levels.
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