Evidence map›Paper›PMID 37221363›Full record

ArticleScientific reports2023

Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells.

Alexandre Joushomme, Rosa Orlacchio, Lorenza Patrignoni, Anne Canovi, Yann Loïck Chappe, Florence Poulletier De Gannes, Annabelle Hurtier, André Garenne, Isabelle Lagroye, François Moisan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Alexandre JoushommeBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
Rosa OrlacchioLimoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.
Lorenza PatrignoniBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
Anne CanoviBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
Yann Loïck ChappeBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
Florence Poulletier De GannesBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
Annabelle HurtierBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
André GarenneBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
Isabelle LagroyeBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France.
François MoisanBordeaux University, INSERM, BMGIC Laboratory, UMR1035, F-33000, Bordeaux, France.
Muriel CarioBordeaux University, INSERM, BMGIC Laboratory, UMR1035, F-33000, Bordeaux, France.
Philippe LévêqueLimoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.
Delia Arnaud-CormosLimoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.
Yann PercherancierBordeaux University, CNRS, IMS laboratory, UMR5218, F-33400, Talence, France. yann.percherancier@ims-bordeaux.fr.
Centre National de la Recherche Scientifique · FRUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential health risks of exposure to radiofrequency electromagnetic fields from mobile communications technologies have raised societal concerns. Guidelines have been set to protect the population (e.g. non-specific heating above 1 °C under exposure to radiofrequency fields), but questions remain regarding the potential biological effects of non-thermal exposures. With the advent of the fifth generation (5G) of mobile communication, assessing whether exposure to this new signal induces a cellular stress response is one of the mandatory steps on the roadmap for a safe deployment and health risk evaluation. Using the BRET (Bioluminescence Resonance Energy-Transfer) technique, we assessed whether continuous or intermittent (5 min ON/ 10 min OFF) exposure of live human keratinocytes and fibroblasts cells to 5G 3.5 GHz signals at specific absorption rate (SAR) up to 4 W/kg for 24 h impact basal or chemically-induced activity of Heat Shock Factor (HSF), RAt Sarcoma virus (RAS) and Extracellular signal-Regulated Kinases (ERK) kinases, and Promyelocytic Leukemia Protein (PML), that are all molecular pathways involved in environmental cell-stress responses. The main results are (i), a decrease of the HSF1 basal BRET signal when fibroblasts cells were exposed at the lower SARs tested (0.25 and 1 W/kg), but not at the highest one (4 W/kg), and (ii) a slight decrease of As

Indexed as

Electromagnetic FieldsExtracellular Signal-Regulated MAP KinasesFibroblastsKeratinocytesHumansExtracellular Signal-Regulated MAP Kinases

Identifiers

PMID37221363
PMCPMC10203668
OpenAlexW4377940477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.