Evidence map›Paper›PMID 37221357›Full record

ReviewNature reviews. Clinical oncology2023

The roles and implications of RNA m

Xiaolan Deng, Ying Qing, David Horne, Huilin Huang, Jianjun Chen

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 237 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 2 pooled it
48.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

237 citing papers in PubMed, 2 syntheses or guidelines pooled it, 316 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026
    Review
  5. Article
  6. Review
  7. Dysregulated mScience advances · 2026
    Article
  8. Hypoxia-induced mGenes & diseases · 2026
    Article
  9. Article
  10. Beyond mBiomedicines · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. mInterdisciplinary sciences, computational life sciences · 2026
    Article

177 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Xiaolan Deng *Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA. xideng@coh.org.ORCID 0000-0003-3695-0203
Ying Qing *Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA.ORCID 0000-0001-6763-6204
David HorneCity of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.
Huilin HuangSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. huanghl1@sysucc.org.cn.ORCID 0000-0003-2608-572X
Jianjun ChenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA. jianchen@coh.org.ORCID 0000-0003-3749-2902
City of Hope · USSun Yat-sen University · CN

Funding

The role and therapeutic potential of IGF2BP2 in MLL-rearranged leukemiaR01CA271497 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Jianjun Chen · 2022 to 2026
$2.8M
Targeting FTO to treat acute myeloid leukemiaR01CA243386 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2024
$2.8M
TET2-mediated epitranscriptomic regulation in leukemia microenvironmentR01CA280389 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Jianjun Chen · 2023 to 2026
$2.7M
The role and mechanism of METTL3/METTL14-mediated RNA modification in the pathogenesis and drug-resistance of AMLR01CA236399 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2019 to 2023
$2.3M
The function and underlying mechanism of TET1 in myelodysplastic syndromesR01DK124116 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2023
$2.2M
The role and mechanism of FTO in leukemogenesis and drug responseR01CA214965 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.1M
Mechanism and therapeutic implication of RNA-modification-mediated codon-biased translation in acute myeloid leukemiaU01CA305196 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Jianjun Chen, XIAOLAN DENG · 2025 to 2026
$1.9M
NCI NIH HHS R01 CA214965NCI NIH HHS R01 CA236399NCI NIH HHS R01 CA243386NCI NIH HHS R01 CA271497NCI NIH HHS R01 CA280389NCI NIH HHS U01 CA305196NIDDK NIH HHS R01 DK124116
6 · The paper itself

Abstract

N

Indexed as

NeoplasmsRNAAdenosineBiomarkersHumansRNA, MessengerTumor MicroenvironmentAdenosineBiomarkersRNARNA, Messenger

Identifiers

PMID37221357
PMCPMC12466201
OpenAlexW4377820759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.