Evidence map›Paper›PMID 37221302›Full record

ArticleCell and tissue research2023

Circ2388 regulates myogenesis and muscle regeneration.

Dandan Zhong, Kongwei Huang, Liyin Zhang, Yudong Cai, Huiren Li, Qingyou Liu, Deshun Shi, Hui Li, Yu Jiang

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Roles of circRNAs in viral pathogenesis.Frontiers in cellular and infection microbiology · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dandan ZhongKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, 712100, Xianyang, Yangling, Shaanxi, China.
Kongwei HuangState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources , College of Animal Science and Technology, Guangxi University, 530004, Nanning, China.
Liyin ZhangState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources , College of Animal Science and Technology, Guangxi University, 530004, Nanning, China.
Yudong CaiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, 712100, Xianyang, Yangling, Shaanxi, China.
Huiren LiAnimal Husbandry Station of Chongzuo City, 532200, Chongzuo, China.
Qingyou LiuState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources , College of Animal Science and Technology, Guangxi University, 530004, Nanning, China.
Deshun ShiState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources , College of Animal Science and Technology, Guangxi University, 530004, Nanning, China.
Hui LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, 712100, Xianyang, Yangling, Shaanxi, China. huili@gxu.edu.cn.ORCID http://orcid.org/0000-0002-5753-8579
Yu JiangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, 712100, Xianyang, Yangling, Shaanxi, China.
Guangxi University · CNNorthwest A&F University · CNFoshan University · CN

Funding

National Natural Science Foundation of China 32102514National Natural Science Foundation of China U20A2051Natural Science Foundation of Guangxi Province 2019GXNSFAA185056Natural Science Foundation of Guangxi Province 2020GXNSFBA297148Postdoctoral Research Foundation of China 2019M663842Science and Technology Base and Talent Special in Guangxi AD20159062
6 · The paper itself

Abstract

The formation of skeletal muscle is a complex process that is coordinated by many regulatory factors, such as myogenic factors and noncoding RNAs. Numerous studies have proved that circRNA is an indispensable part of muscle development. However, little is known about circRNAs in bovine myogenesis. In this study, we discovered a novel circRNA, circ2388, formed by reverse splicing of the fourth and fifth exons of the MYL1 gene. The expression of circ2388 was different between fetal and adult cattle muscle. This circRNA is 99% homologous between cattle and buffalo and is localized in the cytoplasm. Thoroughly, we proved that circ2388 had no effect on cattle and buffalo myoblast proliferation but promotes myoblast differentiation and myotube fusion. Furthermore, circ2388 in vivo stimulated skeletal muscle regeneration in mouse muscle injury model. Taken together, our findings suggest that circ2388 promotes myoblast differentiation and promotes the recovery and regeneration of damaged muscles.

Indexed as

MyoblastsRNA, CircularAnimalsBuffaloesCattleCell DifferentiationCell ProliferationMiceMuscle DevelopmentMuscle Fibers, SkeletalMuscle, SkeletalRNA, CircularBuffaloCattlecircRNAMuscleMyogenesis

Identifiers

PMID37221302
OpenAlexW4377940475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.