Evidence map›Paper›PMID 37221271›Full record

ArticleGene therapy2023

Tolerability and tropism of recombinant adeno-associated virus vectors in the African green monkey (Chlorocebus sabaeus) anterior chamber.

Kristina J Chern, Kimicia Z Issac, Zendorf D Gumbs, Merissa E O'Connor, Matthew S Lawrence, Daniel M Lipinski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kristina J ChernDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-2461-7051
Kimicia Z IssacVirscio, New Haven, CT, USA.
Zendorf D GumbsVirscio, New Haven, CT, USA.
Merissa E O'ConnorVirscio, New Haven, CT, USA.
Matthew S LawrenceVirscio, New Haven, CT, USA.
Daniel M LipinskiDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA. dlipinski@mcw.edu.ORCID http://orcid.org/0000-0001-7828-614X
Virscio (United States) · USMedical College of Wisconsin · US

Funding

Development of an IOP-lowering gene therapy treatment for glaucomaR01EY032478 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI KOMAROMY, ANDRAS, LIPINSKI, DANIEL MARK · 2022 to 2025
$2.6M
NEI NIH HHS R01 EY032478
6 · The paper itself

Abstract

While many studies have investigated the use of recombinant adeno-associated vectors (rAAV) in the posterior chamber for treatment of inherited retinal diseases, fewer studies have looked at rAAV's ability to transduce cells within the anterior chamber. This study focuses on evaluating the tropism and tolerability of three rAAV serotypes-rAAV2/6, rAAV2/9, and rAAV2/2[MAX]-expressing a green fluorescent protein (GFP) reporter following intracameral injection in the non-human primate (NHP) African green monkey (Chlorocebus sabaeus) model. Injection of high dose (1 × 10

Indexed as

DependovirusGenetic VectorsAnimalsAnterior ChamberChlorocebus aethiopsTransduction, GeneticTropism

Identifiers

PMID37221271
PMCPMC11287778
OpenAlexW4377939127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.