Evidence map›Paper›PMID 37221096›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.

Kaikai He, Yifu Han, Xiling Li, Roberto X Hernandez, Danielle V Riboul, Touhid Feghhi, Karlis A Justs, Olena Mahneva, Sarah Perry, Gregory T Macleod and 1 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  5. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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  9. Review
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  11. CaeLife · 2024
    Article
  12. Article
  13. CabioRxiv : the preprint server for biology · 2024
    Article
  14. Neto proteins differentially modulate the gating properties ofbioRxiv : the preprint server for biology · 2024
    Article
  15. Neuromuscular basis ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kaikai HeDepartment of Neurobiology, University of Southern California, Los Angeles, California 90089.ORCID 0000-0003-2002-4862
Yifu HanDepartment of Neurobiology, University of Southern California, Los Angeles, California 90089.ORCID 0000-0002-1201-654X
Xiling LiDepartment of Neurobiology, University of Southern California, Los Angeles, California 90089.
Roberto X HernandezIntegrative Biology and Neuroscience Graduate Program, Department of Biological Sciences, Florida Atlantic University, Boca Raton, Florida 33431.ORCID 0000-0001-9875-3243
Danielle V RiboulIntegrative Biology Graduate Program, Department of Biological Sciences, Florida Atlantic University, Boca Raton, Florida 33431.
Touhid FeghhiDepartment of Physics, Florida Atlantic University, Boca Raton, Florida 33431.
Karlis A JustsIntegrative Biology and Neuroscience Graduate Program, Department of Biological Sciences, Florida Atlantic University, Boca Raton, Florida 33431.
Olena MahnevaWilkes Honors College, Florida Atlantic University, Jupiter, Florida 33458.
Sarah PerryDepartment of Neurobiology, University of Southern California, Los Angeles, California 90089.
Gregory T MacleodWilkes Honors College, Florida Atlantic University, Jupiter, Florida 33458 dickman@usc.edu macleodg@fau.edu.ORCID 0000-0003-3782-6968
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, California 90089 dickman@usc.edu macleodg@fau.edu.ORCID 0000-0003-1884-284X
Florida Atlantic University · USUniversity of Southern California · USMax Planck Florida Institute for Neuroscience · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Generating functional diversity from molecular homogeneity at glutamatergic synapsesR01NS126654 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DION KAI DICKMAN · 2023 to 2026
$1.8M
Synaptic Control of Glutamate HomeostasisR01NS111414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2019 to 2023
$1.8M
The impact of synaptic cleft pH fluctuations on short-term synaptic plasticityR01NS103906 · NINDS · FLORIDA ATLANTIC UNIVERSITY · PI MACLEOD, GREGORY TALISKER · 2019 to 2022
$1.3M
The impact of synaptic cleft pH fluctuations on short-term synaptic plasticityR56NS103906 · NINDS · FLORIDA ATLANTIC UNIVERSITY · PI MACLEOD, GREGORY TALISKER · 2018 to 2018
$395k
NIH HHS P40 OD018537NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS103906NINDS NIH HHS R01 NS111414NINDS NIH HHS R01 NS126654NINDS NIH HHS R56 NS103906
6 · The paper itself

Abstract

Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity patterns, with some neurons firing at a relatively constant "tonic" rate, while others fire in bursts, a "phasic" pattern. Synapses formed by tonic versus phasic neurons are also functionally differentiated, yet the bases of their distinctive properties remain enigmatic. A major challenge toward illuminating the synaptic differences between tonic and phasic neurons is the difficulty in isolating their physiological properties. At the

Indexed as

Neuromuscular JunctionSynapsesAnimalsDrosophilaMotor NeuronsSynaptic Vesiclesactive zoneDrosophilaneuromuscular junctionphasicsynapsetonic

Identifiers

PMID37221096
PMCPMC10286941
OpenAlexW4377711803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.