Impaired Speaking-Induced Suppression in Alzheimer's Disease.
Kyunghee X Kim, Corby L Dale, Kamalini G Ranasinghe, Hardik Kothare, Alexander J Beagle, Hannah Lerner, Danielle Mizuiri, Maria Luisa Gorno-Tempini, Keith Vossel, Srikantan S Nagarajan and 1 more
Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it
What it found
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2 · The registry
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3 · Its place in the literature
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2 citing papers in PubMed, 7 citations in OpenAlex.
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5 · Who and what money
Authors and funding
11 authors at 1 institution in 1 country.
Kyunghee X KimDepartment of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94117 kyunghee.kim@ucsf.edu john.houde@ucsf.edu Srikantan.Nagarajan@ucsf.edu.
Corby L DaleDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117.ORCID 0000-0002-6021-2000
Kamalini G RanasingheDepartment of Neurology, University of California San Francisco, San Francisco, CA 94158.
Hardik KothareDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117.
Alexander J BeagleDepartment of Neurology, University of California San Francisco, San Francisco, CA 94158.
Hannah LernerDepartment of Neurology, University of California San Francisco, San Francisco, CA 94158.
Danielle MizuiriDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117.ORCID 0000-0002-0277-5331
Maria Luisa Gorno-TempiniDepartment of Neurology, University of California San Francisco, San Francisco, CA 94158.
Keith VosselDepartment of Neurology, University of California San Francisco, San Francisco, CA 94158.
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117 kyunghee.kim@ucsf.edu john.houde@ucsf.edu Srikantan.Nagarajan@ucsf.edu.
John F HoudeDepartment of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94117 kyunghee.kim@ucsf.edu john.houde@ucsf.edu Srikantan.Nagarajan@ucsf.edu.
University of California, San Francisco · US
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremorP50DC019900 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2021 to 2026
$11.9M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
The role of the cerebellum in speechR01DC017091 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Francis Houde, RICHARD IVRY · 2019 to 2026
$4.5M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Neuroimaging of Speech Motor ControlR01DC010145 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS · 2010 to 2014
$1.8M
Multimodal modeling framework for fusing structural and functional connectome dataR01EB022717 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2016 to 2018
$1.6M
Role of auditory feedback in speech motor control in Alzheimer's diseaseR01DC017696 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS, NAGARAJAN, SRIKANTAN S. · 2018 to 2020
$1.5M
Neurophysiological Assessments of Network Dysfunction in Alzheimer's DiseaseK08AG058749 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANASINGHE, KAMALINI GAYATHREE · 2019 to 2023
$859k
Mechanisms and Treatment of Network Dysfunction in Alzheimer's DiseaseK23AG038357 · NIA · J. DAVID GLADSTONE INSTITUTES · PI VOSSEL, KEITH ALAN · 2011 to 2015
$764k
Fusion of Electromagnetic Brain Imaging and fMRIR21NS076171 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGARAJAN, SRIKANTAN S. · 2011 to 2012
Alzheimer's disease (AD) is a neurodegenerative disease involving cognitive impairment and abnormalities in speech and language. Here, we examine how AD affects the fidelity of auditory feedback predictions during speaking. We focus on the phenomenon of speaking-induced suppression (SIS), the auditory cortical responses' suppression during auditory feedback processing. SIS is determined by subtracting the magnitude of auditory cortical responses during speaking from listening to playback of the same speech. Our state feedback control (SFC) model of speech motor control explains SIS as arising from the onset of auditory feedback matching a prediction of that feedback onset during speaking, a prediction that is absent during passive listening to playback of the auditory feedback. Our model hypothesizes that the auditory cortical response to auditory feedback reflects the mismatch with the prediction: small during speaking, large during listening, with the difference being SIS. Normally, during speaking, auditory feedback matches its predictions, then SIS will be large. Any reductions in SIS will indicate inaccuracy in auditory feedback prediction not matching the actual feedback. We investigated SIS in AD patients [
Indexed as
Alzheimer DiseaseAuditory CortexNeurodegenerative DiseasesAuditory PerceptionFemaleHumansMiddle AgedSpeechAlzheimer’s diseaseefference copymagnetoencephalographyspeaking-induced suppressionstate feedback control model
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Impaired Speaking-Induced Suppression in Alzheimer's Disease. · full record | OpenQuestion