Evidence map›Paper›PMID 37221015›Full record

ArticleThe Journal of infectious diseases2023

Changes in Inflammatory Markers in Patients Treated for Buruli Ulcer and Their Ability to Predict Paradoxical Reactions.

Michael Phelippeau, Estelle Marion, Marie Robbe-Saule, Line Ganlanon, Annick Chauty, Ambroise Adeye, Simon Blanchard, Christian Johnson, Laurent Marsollier, Vincent Dubee

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Michael PhelippeauService des Maladies Infectieuses et Tropicales, University Hospital Angers.
Estelle MarionUniversité Angers, Nantes Université, Inserm, Immunology and New Concepts in ImmunoTherapy, Immunology and New Concepts in Immunotherapy (INCIT), Angers, France.ORCID 0000-0003-4917-9665
Marie Robbe-SauleUniversité Angers, Nantes Université, Inserm, Immunology and New Concepts in ImmunoTherapy, Immunology and New Concepts in Immunotherapy (INCIT), Angers, France.
Line GanlanonCentre de dépistage et de traitement de la lèpre et de l'ulcère de Buruli, Centre de diagnostic et de traitement de la lèpre et de l'ulcère de Buruli, Pobè, Benin.
Annick ChautyCentre de dépistage et de traitement de la lèpre et de l'ulcère de Buruli, Centre de diagnostic et de traitement de la lèpre et de l'ulcère de Buruli, Pobè, Benin.
Ambroise AdeyeCentre de dépistage et de traitement de la lèpre et de l'ulcère de Buruli, Centre de diagnostic et de traitement de la lèpre et de l'ulcère de Buruli, Pobè, Benin.
Simon BlanchardUniversité Angers, Nantes Université, Inserm, Centre National de la Recherche Scientifique (CNRS), Nantes - Angers Cancer and Immunology Research Center (CRCINA2).
Christian JohnsonCenter inter facultaire de formation et de recherche en environnement (CIFRED), Université d'Abomey Calavi, Abomey Calavi, Benin.
Laurent MarsollierUniversité Angers, Nantes Université, Inserm, Immunology and New Concepts in ImmunoTherapy, Immunology and New Concepts in Immunotherapy (INCIT), Angers, France.
Vincent DubeeService des Maladies Infectieuses et Tropicales, University Hospital Angers.
Inserm · FRCentre National de la Recherche Scientifique · FRHospital for Tropical Diseases · VNUniversité d'Abomey-Calavi · BJ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium ulcerans causes Buruli ulcer, the third most frequent mycobacterial disease after tuberculosis and leprosy. Transient clinical deteriorations, known as paradoxical reactions (PRs), occur in some patients during or after antibiotic treatment. We investigated the clinical and biological features of PRs in a prospective cohort of 41 patients with Buruli ulcer from Benin. Neutrophil counts decreased from baseline to day 90, and interleukin 6 (IL-6), granulocyte colony-stimulating factor, and vascular endothelial growth factor were the cytokines displaying a significant monthly decrease relative to baseline. PRs occurred in 10 (24%) patients. The baseline biological and clinical characteristics of the patients presenting with PRs did not differ significantly from those of the other patients. However, the patients with PRs had significantly higher IL-6 and tumor necrosis factor alpha (TNF-α) concentrations on days 30, 60, and 90 after the start of antibiotic treatment. The absence of a decrease in IL-6 and TNF-α levels during treatment should alert clinicians to the possibility of PR onset.

Indexed as

Buruli UlcerAnti-Bacterial AgentsHumansInterleukin-6Prospective StudiesTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AAnti-Bacterial AgentsInterleukin-6Tumor Necrosis Factor-alphaVascular Endothelial Growth Factor ABuruli ulcerinflammatory responseMycobacterium ulceransparadoxical reaction

Identifiers

PMID37221015
PMCPMC10681857
OpenAlexW4377694530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.