Evidence map›Paper›PMID 37220495›Full record

ArticleProceedings of machine learning research2022

TopoFit: Rapid Reconstruction of Topologically-Correct Cortical Surfaces.

Andrew Hoopes, Juan Eugenio Iglesias, Bruce Fischl, Douglas Greve, Adrian V Dalca

Abstract read
In one paragraph

Article in Proceedings of machine learning research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Unified Brain Surface and Volume Registration.... International Conference on Learning Representations · 2026
    Article
  4. DEEP-GYRALNET: ENABLING MACHINE LEARNING IN GYRAL FOLDING PATTERN EXTRACTION ON CORTICAL SURFACE.Proceedings. IEEE International Symposium on Biomedical Imaging · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Pseudo-Rendering for Resolution and Topology-Invariant Cortical Parcellation.Machine learning in medical imaging. MLMI (Workshop) · 2025
    Article
  10. Synthetic data in generalizable, learning-based neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  11. Coupled Reconstruction of Cortical Surfaces by Diffeomorphic Mesh Deformation.Advances in neural information processing systems · 2023
    Article
  12. Article
  13. Proceedings. IEEE International Symposium on Biomedical Imaging · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew HoopesMartinos Center for Biomedical Imaging, Massachusetts General Hospital.
Juan Eugenio IglesiasMartinos Center for Biomedical Imaging, Massachusetts General Hospital.
Bruce FischlMartinos Center for Biomedical Imaging, Massachusetts General Hospital.
Douglas GreveMartinos Center for Biomedical Imaging, Massachusetts General Hospital.
Adrian V DalcaMartinos Center for Biomedical Imaging, Massachusetts General Hospital.

Funding

EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BRUCE R ROSEN · 2020 to 2026
$10.9M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain Admin SupplementU01MH117023 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A, FISCHL, BRUCE · 2018 to 2022
$7.6M
Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1M
FreeSurfer Development, Maintenance, and HardeningR01EB023281 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Douglas Nowlin Greve · 2016 to 2026
$5.6M
A Longitudinal Analysis Stream for FreeSurferR01NS083534 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2014 to 2026
$4.6M
Deep Learning Algorithms for FreeSurferR01AG064027 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2020 to 2024
$3.4M
Segmenting Brain Structures for Neurological DisordersR01NS105820 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2019 to 2026
$3.2M
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanningR01AG070988 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI IGLESIAS GONZALEZ, JUAN EUGENIO · 2021 to 2025
$2.7M
NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG064027NIA NIH HHS R01 AG070988NIA NIH HHS R56 AG064027NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41 EB030006NIBIB NIH HHS R01 EB006758NIBIB NIH HHS R01 EB019956NIBIB NIH HHS R01 EB023281NIBIB NIH HHS R21 EB018907NIMH NIH HHS RF1 MH121885NIMH NIH HHS RF1 MH123195NIMH NIH HHS U01 MH093765NIMH NIH HHS U01 MH117023NINDS NIH HHS R01 NS070963NINDS NIH HHS R01 NS083534NINDS NIH HHS R01 NS105820NINDS NIH HHS R21 NS072652NINDS NIH HHS U01 NS086625
6 · The paper itself

Abstract

Mesh-based reconstruction of the cerebral cortex is a fundamental component in brain image analysis. Classical, iterative pipelines for cortical modeling are robust but often time-consuming, mostly due to expensive procedures that involve topology correction and spherical mapping. Recent attempts to address reconstruction with machine learning methods have accelerated some components in these pipelines, but these methods still require slow processing steps to enforce topological constraints that comply with known anatomical structure. In this work, we introduce a novel learning-based strategy, TopoFit, which rapidly fits a topologically-correct surface to the white-matter tissue boundary. We design a joint network, employing image and graph convolutions and an efficient symmetric distance loss, to learn to predict accurate deformations that map a template mesh to subject-specific anatomy. This technique encompasses the work of current mesh correction, fine-tuning, and inflation processes and, as a result, offers a 150× faster solution to cortical surface reconstruction compared to traditional approaches. We demonstrate that TopoFit is 1.8× more accurate than the current state-of-the-art deep-learning strategy, and it is robust to common failure modes, such as white-matter tissue hypointensities.

Indexed as

Cortical Surface ReconstructionGeometric Deep-LearningTopology

Identifiers

PMID37220495
PMCPMC10201930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.