Evidence map›Paper›PMID 37219667›Full record

ArticleMolecular biology reports2023

Association of endothelial nitric oxide synthase (Glu298Asp) gene polymorphism with radial artery spasm during cardiac catheterization in Egyptians.

Tarek A Abdelaziz, Randa H Mohamed, Ashraf A Dwedar, Mohey Eldeen A Eldeeb, Abdelrahman A Abdelfattah, Sara F Saadawy

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tarek A AbdelazizCardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Randa H MohamedMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. randahussiny@yahoo.com.ORCID http://orcid.org/0000-0003-2983-9232
Ashraf A DwedarCardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohey Eldeen A EldeebCardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abdelrahman A AbdelfattahCardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Sara F SaadawyMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNitric oxide (NO) exerts diverse effects on the cardiovascular system. Impairment of NO production plays a key role in cerebral and coronary artery spasm. We aimed to explore the predicting factors of radial artery spasm (RAS) and the association of eNOS gene polymorphism (Glu298Asp) with RAS during cardiac catheterization. METHODS AND

results200 patients underwent elective coronary angiography through a trans-radial approach. The subjects were genotyped to the Glu298Asp polymorphism (rs1799983) on the eNOS gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Our results showed that the subjects with the TT genotype and T allele were significantly more likely to develop radial artery spasms (OR = 12.5, 4.6, P < 0.001 respectively). TT genotype of eNOS Glu298Asp polymorphism, number of punctures, size of the radial sheath, radial tortuosity, and right radial access are independent predictors of radial spasm.

conclusionThe eNOS (Glu298Asp) gene polymorphism is associated with RAS during cardiac catheterization in Egyptians. TT genotype of eNOS Glu298Asp polymorphism, number of punctures, size of the radial sheath, right radial access, and tortuosity are independent predictors of RAS during cardiac catheterization.

Indexed as

Arterial Occlusive DiseasesCardiac CatheterizationNitric Oxide Synthase Type IIIRadial ArteryCatheterization, PeripheralGenotypeHumansNitric OxideNorth African PeoplePolymorphism, GeneticRisk FactorsNitric OxideNitric Oxide Synthase Type IIINOS3 protein, humaneNOS geneGlu298Asp polymorphismRadial artery spasm

Identifiers

PMID37219667
PMCPMC10289915

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.