Evidence map›Paper›PMID 37219665›Full record

ArticleMolecular biology reports2023

Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.

Grace Kelly Lee, Hae-Yeong Kim, Jong Hwan Park

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  3. Vaccines · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Grace Kelly LeeChingchai Wanidworanun, MD PLLC, 4001 9th St N Suite 228, Arlington, VA, 22203, USA.
Hae-Yeong KimInstitute of Life Science and Resources and Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104, South Korea. hykim@khu.ac.kr.
Jong Hwan ParkResearch Institute of Medical Science, School of Medicine, KonKuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea. nihpark@yahoo.com.
Konkuk University · KRKyung Hee University · KR

Funding

National Research Foundation of Korea NRF-2014R1A1A2058125
6 · The paper itself

Abstract

backgroundEukaryotic initiation factor 5A hypusine (eIF5A METHODS AND

resultsWestern blotting and dual luciferase analyses showed that depletion of eIF5A

conclusionThe depletion of eIF5A

Indexed as

ApoptosisOvarian NeoplasmsAdaptor Proteins, Signal TransducingCell Cycle ProteinsCell Line, TumorCell ProliferationEukaryotic Translation Initiation Factor 5AFemaleHumansPeptide Initiation FactorsProtein Serine-Threonine KinasesRNA, Small InterferingAdaptor Proteins, Signal TransducingCell Cycle ProteinsEIF4EBP1 protein, humanEukaryotic Translation Initiation Factor 5APeptide Initiation FactorsProtein Serine-Threonine KinasesRNA, Small Interferingsalt-inducible kinase-2, human4E-BP1 (Ser 65)eIF5AHypGC7SIK2

Identifiers

PMID37219665
OpenAlexW4377565650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.