Evidence map›Paper›PMID 37219649›Full record

ReviewMedical oncology (Northwood, London, England)2023

The past, present, and future of immunotherapy for endometrial adenocarcinoma.

Anna C Jones, Karah H Brown, Tianyun Guan, Luke A Smith, Cole R Formslag, Emerson D Farjado, Qian Bai, Harrison D Luechtefeld, Mark R Wakefield, Lijun Dong and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Anna C JonesDepartment of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA.
Karah H BrownDepartment of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA.
Tianyun Guan *Department of Obstetrics and Gynecology, The Nanhua Hospital Affiliated to Nanhua University, Hengyang, China.
Luke A SmithDepartment of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Cole R FormslagDepartment of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA.
Emerson D FarjadoDepartment of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Qian BaiDepartment of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Harrison D LuechtefeldDepartment of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Mark R WakefieldDepartment of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Lijun DongDepartment of Obstetrics and Gynecology, The Nanhua Hospital Affiliated to Nanhua University, Hengyang, China. donglijunys@163.com.
Yujiang FangDepartment of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA. yujiang.fang@dmu.edu.ORCID http://orcid.org/0000-0002-9107-7374
University of Missouri · USUniversity of South China · CNDes Moines University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incidences of endometrial adenocarcinoma are increasing in the USA with poor prognosis for patients with advanced disease. The current treatment standard is surgery including total hysterectomy and bilateral oophorectomy with surgical staging and adjunct treatment, such as chemotherapy or radiation. However, these methods do not present as an effective treatment option for poorly differentiated advanced cancers. Advancements in immunotherapy now offer a new approach for various types of cancer and specifically show promise in the treatment of endometrial adenocarcinoma. This review summarizes immunotherapeutic treatment options relevant to endometrial adenocarcinoma, such as immune checkpoint blockades, bispecific T-cell engager antibodies, vaccinations, and adoptive cell transfer. This study could be helpful for clinicians to identify treatment options more suitable for women with late-stage endometrial adenocarcinoma.

Indexed as

AdenocarcinomaImmunotherapyFemaleHumansHysterectomyImmunotherapy, AdoptiveVaccinationEndometrial cancerImmunotherapy

Identifiers

PMID37219649
OpenAlexW4377564766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.