SynthesisLangenbeck's archives of surgery2023
Varying negative appendectomy rates after laparoscopic appendectomy: a systematic review and meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- A hybrid machine learning approach to improve the diagnostic accuracy of acute appendicitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- A Twist in the Tale: Rare Diagnosis of Lipomatosis of the Appendix.Case reports in surgery · 2026Article
- Case Report: ERAT-based management of appendiceal abscess in early pregnancy.Frontiers in surgery · 2026Article
- Efficacy of endoscopic retrograde appendicitis therapy in children with suppurative vs. simple appendicitis: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Reduced recurrence rate with a targeted approach in uncomplicated appendicitis treated with endoscopic directWorld journal of gastroenterology · 2025Article
- Article
- Article
- Complicated appendicitis: value of inflammatory markers based on EAES 2015 guidelines.Surgical endoscopy · 2025Article
- Cholangioscope-Assisted ERAT: The Light at the End of a Blind Tunnel?Digestive diseases and sciences · 2025Article
- Misses and Near Misses in Paediatric Appendicitis: An Eight-Year, Single-Centre Retrospective Review.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Therapeutic effectiveness and influencing factors of laparoscopic appendectomy with mesoappendix dissection in the treatment of acute appendicitis.World journal of gastrointestinal surgery · 2025Article
- European surgical societies rarely have recommendations for the treatment of appendicitis - a survey.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Direct visualization endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy for management of acute uncomplicated appendicitis.Endoscopy international open · 2025Article
- The diagnostic utility of urinary 5-HIAA and leucine-rich alpha-2 glycoprotein in acute appendicitis: a narrative review.Frontiers in medicine · 2025Review
- Patient reported outcomes after laparoscopic appendectomy for acute appendicitis.Langenbeck's archives of surgery · 2024Article
- Time to improve the management of patients with suspected acute appendicitis: a retrospective study.Abdominal radiology (New York) · 2024Article
- Patients' attitudes toward negative appendectomies and surgery for suspected appendicitis: a qualitative interview study.Surgical endoscopy · 2024Article
- Is appendoscope a new option for the treatment of acute appendicitis?World journal of gastroenterology · 2024Review
- Risk Factors Associated With Negative Appendicectomy Rates: A Retrospective Cohort Study.Cureus · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAppendicitis is a common cause of acute abdominal pain, and treatment with laparoscopy has become increasingly common during the past two decades. Guidelines recommend that normal appendices are removed if operated for suspected acute appendicitis. It is unclear how many patients are affected by this recommendation. The aim of this study was to estimate the rate of negative appendectomies in patients undergoing laparoscopic surgery for suspected acute appendicitis.
methodsThis study was reported following the PRISMA 2020 statement. A systematic search was conducted in PubMed and Embase for retrospective or prospective cohort studies (with n ≥ 100) including patients with suspected acute appendicitis. The primary outcome was the histopathologically confirmed negative appendectomy rate after a laparoscopic approach with a 95% confidence interval (CI). We performed subgroup analyses on geographical region, age, sex, and use of preoperative imaging or scoring systems. The risk of bias was assessed using the Newcastle-Ottawa Scale. Certainty of the evidence was assessed using GRADE.
resultsIn total, 74 studies were identified, summing up to 76,688 patients. The negative appendectomy rate varied from 0% to 46% in the included studies (interquartile range 4-20%). The meta-analysis estimated the negative appendectomy rate to be 13% (95% CI 12-14%) with large variations between the individual studies. Sensitivity analyses did not change the estimate. The certainty of evidence by GRADE was moderate due to inconsistency in point estimates.
conclusionThe overall estimated negative appendectomy rate after laparoscopic surgery was 13% with moderate certainty of evidence. The negative appendectomy rate varied greatly between studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.