SynthesisRadiology2023
Standalone AI for Breast Cancer Detection at Screening Digital Mammography and Digital Breast Tomosynthesis: A Systematic Review and Meta-Analysis.
Abstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Italian guidelines for the use of digital breast tomosynthesis in breast cancer screening programmes: GRADE-ADOLOPMENT of the European guidelines.La Radiologia medica · 2026Guideline
- Deep Learning Algorithms Versus Radiologists in Digital Breast Tomosynthesis for Breast Cancer Detection: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- ESR Essentials: artificial intelligence in breast imaging-practice recommendations by the European Society of Breast Imaging.European radiology · 2026Guideline
- Artificial Intelligence Performance in Image-Based Cancer Identification: Umbrella Review of Systematic Reviews.Journal of medical Internet research · 2025Pooled it
- Tomosynthesis and Synthesized-2D Breast AI Outputs in a Biopsy-Referred Cohort: A Diagnostic Study of Agreement and Incremental Decision-Support Value.Journal of imaging informatics in medicine · 2026Article
- Reading time in AI-assisted mammography: no measurable time penalty.European radiology · 2026Article
- Ten Years of Artificial Intelligence in Screening Mammography: A Systematic Review and Meta-Analysis of Diagnostic Accuracy and Clinical Implementation (Literature Published 2015-2025).Diagnostics (Basel, Switzerland) · 2026Review
- Artificial intelligence-based multimodal integration of ultrasound and digital breast tomosynthesis for breast-level risk classification.Precision clinical medicine · 2026Article
- Implementation of an artificial intelligence-based system for mammography in the compulsory medical insurance program: results of a 3-year study.Quantitative imaging in medicine and surgery · 2026Article
- AI performance varies considerably across mammography devices: a multi-site and multi-vendor retrospective study.Insights into imaging · 2026Article
- Using Artificial Intelligence to Improve Timeliness of Follow-Up in Breast Cancer Screening.Journal of the American College of Radiology : JACR · 2026Article
- Missed and true interval cancers on digital breast tomosynthesis screening mammograms: radiologists' assessment and artificial intelligence markings.Acta radiologica open · 2026Article
- Landmark Regression with Attention U-Net for Assessing Breast Positioning Quality in MLO Mammography View.Diagnostics (Basel, Switzerland) · 2026Article
- Deep Learning for Early Breast Cancer Detection on Contrast-Enhanced Breast MRI: A Multicenter Study.Cancers · 2026Article
- AI in mammography reporting: transparency, trust, and the patient perspective.European radiology · 2026Article
- Comparing clinical decision-making between colposcopists and large language models in cervical dysplasia management: a pilot prospective multicenter study.Archives of gynecology and obstetrics · 2026Article
- Artificial Intelligence in Early Breast Cancer Detection: A Systematic Review of Innovations in Preventive Women's Healthcare.Healthcare (Basel, Switzerland) · 2026Review
- How much radiologist time can be saved by implementing AI in screen-reading mammograms?European radiology · 2026Article
- Reading the future: how AI rewrites mammography workflows.European radiology · 2026Article
- Radiologist burnout: AI's true black box.European radiology · 2026Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Jung Hyun YoonFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0002-2100-3513
Fredrik StrandFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0003-3910-7086
Pascal A T BaltzerFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0002-3755-5398
Emily F ConantFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0001-9331-644X
Fiona J GilbertFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).
Constance D LehmanFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0001-5839-6675
Elizabeth A MorrisFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0001-5069-0992
Lisa A MullenFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0003-3191-2865
Robert M NishikawaFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0001-7720-9951
Nisha SharmaFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0003-3991-0768
Ilse VejborgFrom the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0002-2329-203X
Linda Moy *From the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0001-9564-9360
Ritse M Mann *From the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea (J.H.Y.); Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (F.S.); Department of Radiology, Unit of Breast Imaging, Karolinska University Hospital, Stockholm, Sweden (F.S.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (P.A.T.B.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (E.F.C.); Department of Radiology, University of Cambridge, Cambridge, UK (F.J.G.); Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass (C.D.L.); Department of Radiology, University of California Davis, Davis, Calif (E.A.M.); Department of Radiology, Breast Imaging Division, Johns Hopkins Medicine, Baltimore, Md (L.A.M.); Department of Radiology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, Pa (R.M.N.); Department of Radiology, St James Hospital, Leeds, UK (N.S.); Department of Breast Examinations, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark (I.V.); Department of Radiology, Laura and Isaac Perlmutter Cancer Center, Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY (L.M.); Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (R.M.M.).ORCID 0000-0001-8111-1930
Funding
TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3MCancer Research UK 26884NIBIB NIH HHS P41 EB017183
Abstract
Background There is considerable interest in the potential use of artificial intelligence (AI) systems in mammographic screening. However, it is essential to critically evaluate the performance of AI before it can become a modality used for independent mammographic interpretation. Purpose To evaluate the reported standalone performances of AI for interpretation of digital mammography and digital breast tomosynthesis (DBT). Materials and Methods A systematic search was conducted in PubMed, Google Scholar, Embase (Ovid), and Web of Science databases for studies published from January 2017 to June 2022. Sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) values were reviewed. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 and Comparative (QUADAS-2 and QUADAS-C, respectively). A random effects meta-analysis and meta-regression analysis were performed for overall studies and for different study types (reader studies vs historic cohort studies) and imaging techniques (digital mammography vs DBT). Results In total, 16 studies that include 1 108 328 examinations in 497 091 women were analyzed (six reader studies, seven historic cohort studies on digital mammography, and four studies on DBT). Pooled AUCs were significantly higher for standalone AI than radiologists in the six reader studies on digital mammography (0.87 vs 0.81,
Indexed as
Artificial IntelligenceBreast NeoplasmsBreastEarly Detection of CancerFemaleHumansMammographyRetrospective Studies
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