Evidence map›Paper›PMID 37219363›Full record

ReviewJournal of materials chemistry. B2023

Targeting endosomal receptors, a new direction for polymers in nanomedicine.

Paulina D Ramirez-Garcia, Nicholas A Veldhuis, Nigel W Bunnett, Thomas P Davis

Abstract readReview
In one paragraph

Review in Journal of materials chemistry. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Emerging therapeutic approaches for treating abdominal pain.Journal of the Canadian Association of Gastroenterology · 2025
    Review
  2. Review
  3. Review
  4. Pain Signaling by GPCRs and RTKs.Trends in pharmacological sciences · 2025
    Review
  5. PARBiomaterials · 2025
    Article
  6. Article
  7. Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Targeting sensory neuron GPCRs for peripheral neuropathic pain.Trends in pharmacological sciences · 2023
    Review
  9. Engineering Nanoscale Drug Delivery Systems for Pain.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paulina D Ramirez-GarciaDentistry Translational Research Center, New York University College of Dentistry, New York, 10010, USA. pr2336@nyu.edu.
Nicholas A VeldhuisMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.ORCID 0000-0002-8902-9365
Nigel W BunnettDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA.
Thomas P DavisAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia. t.davis@uq.edu.au.ORCID 0000-0003-2581-4986

Funding

Endosomal Platforms for Signaling PainR01NS102722 · NINDS · NEW YORK UNIVERSITY · PI NIGEL W BUNNETT, Brian L Schmidt · 2017 to 2026
$3.4M
Trafficking-Dependent Signaling of Pain by Protease-Activated ReceptorsR01DK118971 · NIDDK · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2021
$3.2M
NIDDK NIH HHS R01 DK118971NINDS NIH HHS R01 NS102722
6 · The paper itself

Abstract

In this perspective, we outline a new opportunity for exploiting nanoparticle delivery of antagonists to target G-protein coupled receptors localized in intracellular compartments. We discuss the specific example of antagonizing endosomal receptors involved in pain to develop long-lasting analgesics but also outline the broader application potential of this delivery approach. We discuss the materials used to target endosomal receptors and indicate the design requirements for future successful applications.

Indexed as

EndosomesNanomedicineAnimalsDrug Delivery SystemsHumansHydrogen-Ion ConcentrationNanoparticlesPolymersPolymers

Identifiers

PMID37219363
PMCPMC10641892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.