Evidence map›Paper›PMID 37218539›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Global rural health disparities in Alzheimer's disease and related dementias: State of the science.

Lisa Ann Kirk Wiese, Allison Gibson, Marc Aaron Guest, Amy R Nelson, Raven Weaver, Aditi Gupta, Owen Carmichael, Jordan P Lewis, Allison Lindauer, Samantha Loi and 35 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Lisa Ann Kirk WieseC.E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, Florida, USA.
Allison GibsonUniversity of Kentucky College of Social Work, University of Kentucky, Lexington, Kentucky, USA.
Marc Aaron GuestCenter for Innovation in Healthy and Resilient Aging, Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona, USA.
Amy R NelsonFrederick P. Whiddon College of Medicine, Department of Physiology & Cell Biology, University of South Alabama, Mobile, Alabama, USA.
Raven WeaverDepartment of Human Development, Washington State University, Pullman, Washington, USA.
Aditi GuptaDivision of Nephrology and Hypertension, Department of Internal Medicine, Neurology, Alzheimer's Disease Research Center, University of Kansas, Kansas City, Kansas, USA.
Owen CarmichaelPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Jordan P LewisMemory Keepers Medical Discovery Team, University of Minnesota Medical School, Duluth, Minnesota, USA.
Allison LindauerOregon Alzheimer's Disease Research Center, Oregon Health & Science University, Portland, Oregon, USA.
Samantha LoiNeuropsychiatry, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Rachel PetersonUniversity of Montana School of Public and Community Health Sciences, Missoula, Montana, USA.
Kylie RadfordSchool of Psychology, University of New South Wales, Sydney, Australia.
Elizabeth K RhodusUniversity of Kentucky College of Social Work, University of Kentucky, Lexington, Kentucky, USA.
Christina G WongCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.
Megan ZuelsdorffSchool of Nursing, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ladan Ghazi SaidiDepartment of Communication Disorders, Center for Brain Biology and Behavior (CB3), University of Nebraska at Kearney, and Lincoln, Nebraska, USA.
Esmeralda Valdivieso-MoraDepartment of Psychology and Public Health, Universidad Centroamericana José Simeón Cañas, El Salvador, El Salvador.
Sanne FranzenDepartment of Neurology and Alzheimer Center, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Caitlin N PopeDepartment of Health, Behavior, & Society, University of Kentucky, Lexington, Kentucky, USA.
Timothy S KillianHuman Development and Family Sciences, University of Arkansas, Fayetteville, Arkansas, USA.
Hom L ShresthaSchool of Kinesiology and Health Sciences, Laurentian University, Sudbury, Ontario, Canada.
Patricia C HeynCenter for Optimal Aging, Department of Physical Therapy, Marymount University, Arlington, Virginia, USA.
Ted Kheng Siang NgDepartment of Psychology, Arizona State University, Phoenix, Arizona, USA.
Beth PrusaczykInstitute for Informatics (I2), Center for Population Health Informatics at I2, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Samantha JohnDepartment of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, Nevada, USA.
Ambar KulshreshthaDepartment of Family and Preventive Medicine, Division of Hospital Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Julia L ShefflerCenter for Translational Behavioral Science, Florida State University College of Medicine, Tallahassee, Florida, USA.
Lilah BesserComprehensive Center for Brain Health, University of Miami Miller School of Medicine, Boca Raton, Florida, USA.
Valerie DanielComprehensive Center for Brain Health, University of Miami Miller School of Medicine, Boca Raton, Florida, USA.
Magdalena I ToleaComprehensive Center for Brain Health, University of Miami Miller School of Medicine, Boca Raton, Florida, USA.
Justin MillerCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.
Christine MusyimiAfrica Mental Health Research and Training Foundation, Nairobi, Kenya.
Jon CorkeyAmissa, Charlotte, North Carolina, USA.
Veronica YankDepartment of Medicine, University of California, San Francisco, USA.
Christine L WilliamsC.E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, Florida, USA.
Zahra RahemiClemson School of Nursing, Clemson University, Clemson, South Carolina, USA.
JuYoung ParkSandler School of Social Work, College of Social Work and Criminal Justice, Florida Atlantic University, Boca Raton, Florida, USA.
Sheryl MagzamenDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
Robert L NewtonPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Candace HarringtonSchool of Nursing, University of Louisville, Louisville, Kentucky, USA.
Jason D FlattSchool of Public Health, Department of Social & Behavioral Health, University of Nevada, Las Vegas, USA.
Sonakshi AroraCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.
Sarah WalterDepartment of Clinical Research and Leadership, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Percy GriffinAlzheimer's Therapeutic Research Institute, Alzheimer's Clinical Trials Consortium, University of Southern California, San Diego, California, USA.
Ganesh M BabulalScientific Engagement, Medical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.

Funding

Physical activity, physical function, and frailty in relation to cognitive impairment and AD/ADRD biomarkers in DPPOSU19AG078558 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jose Alejandro Luchsinger, DAVID M NATHAN · 2022 to 2026
$82.5M
Education and Cognitive Functioning in Later Life: The Nation’s High School Class of 1972U01AG078533 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI Eric Grodsky, CHANDRA L MULLER · 2024 to 2026
$36.0M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI JESSICA KIRKLAND CALDWELL · 2015 to 2026
$22.8M
Education and Cognitive Functioning in Later Life: The Nation’s High School Class of 1972R01AG078533 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI GRODSKY, ERIC, MULLER, CHANDRA L · 2022 to 2023
$14.2M
I3C DECADE: Disparities and Equity in Childhood Cardiovascular Exposures and Alzheimer's DementiaR01AG077497 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2022 to 2025
$11.9M
Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive DeclineR33AG068483 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BURNS, JEFFREY MURRAY, GUPTA, ADITI · 2021 to 2024
$11.4M
Supplement for Kentucky BIRCWH Program: Training the Next Generation of Women's Health Scholars: Dr. ConnerK12DA035150 · NIDA · UNIVERSITY OF KENTUCKY · PI Thomas E Curry · 2012 to 2026
$9.0M
Naturalistic driving as a functional neurobehavioral marker of preclinical and symptomatic Alzheimer diseaseR01AG068183 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$6.7M
Preclinical Alzheimer Disease and DrivingR01AG056466 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2017 to 2021
$5.9M
NCCIH NIH HHS R13 AT011146NIA NIH HHS K01 AG063895NIA NIH HHS K01 AG064047NIA NIH HHS K01 AG071749NIA NIH HHS K23 AG055666NIA NIH HHS K23 AG066931NIA NIH HHS K23 AG075262NIA NIH HHS P20 AG068053NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG072946NIA NIH HHS R00 AG058780NIA NIH HHS R00 AG073457NIA NIH HHS R01 AG041200NIA NIH HHS R01 AG056466NIA NIH HHS R01 AG057855NIA NIH HHS R01 AG062200NIA NIH HHS R01 AG062309NIA NIH HHS R01 AG067428NIA NIH HHS R01 AG067546NIA NIH HHS R01 AG067765NIA NIH HHS R01 AG068183NIA NIH HHS R01 AG069476NIA NIH HHS R01 AG072057NIA NIH HHS R01 AG074302NIA NIH HHS R01 AG077000NIA NIH HHS R01 AG077497NIA NIH HHS R01 AG078533NIA NIH HHS R03 AG063303NIA NIH HHS R03 AG063304NIA NIH HHS R13 AG072884NIA NIH HHS R21 AG075291NIA NIH HHS R33 AG068483NIA NIH HHS R43 AG072981NIA NIH HHS R56 AG064094NIA NIH HHS R61 AG068483NIA NIH HHS RF1 AG041200NIA NIH HHS RF1 AG042978NIA NIH HHS U01 AG078533NIA NIH HHS U19 AG078558NIDA NIH HHS K12 DA035150NIGMS NIH HHS P20 GM109025
6 · The paper itself

Abstract

introductionIndividuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators.

methodsAn interdisciplinary, international group of ADRD researchers convened to address the overarching question of: "What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?" In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings.

resultsA range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions. DISCUSSION: A location dynamics model and ADRD-focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities. HIGHLIGHTS: Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities. Defining the unique rural barriers and facilitators to cognitive health yields insight. The strengths and resilience of rural residents can mitigate ADRD-related challenges. A novel "location dynamics" model guides assessment of rural-specific ADRD issues.

Indexed as

Alzheimer DiseaseHumansRisk FactorsRural HealthRural Populationcommunity-based actioncommunity engagementfacilitators and barriers to ADRD diagnosis and treatmentglobal disparitieshealth disparitieslocation dynamicsmodifiable ADRD risk factorsruralrural cultureunder-representedunderserved

Identifiers

PMID37218539
PMCPMC10524180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.