ArticleAnnals of surgery2023
Prognostic Effect of Liver Resection in Extended Cholecystectomy for T2 Gallbladder Cancer Revisited: A Retrospective Cohort Study With Propensity Score-matched Analysis.
Article in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Postoperative prognostic factors in patients with T2 gallbladder cancer: a meta-analysis.World journal of surgical oncology · 2025Pooled it
- Optimal surgical strategies in patients with T1 and T2 gallbladder cancer: necessity of lymph node dissection and liver resection: A retrospective cohort study.International journal of surgery (London, England) · 2026Article
- Nerve growth factor: what can surgeons and oncologists learn from a neurological and psychological biomarker?Molecular medicine (Cambridge, Mass.) · 2025Review
- Recent Trends in Surgical Strategies of Early-Stage Gallbladder Cancer: A Narrative Review.Journal of clinical medicine · 2025Review
- Hotspots and scientometrics in gallbladder cancer surgery research: a bibliometric and visualization analysis (2014-2024).Frontiers in oncology · 2025Article
- De-escalating surgical treatment in low stage gallbladder cancer.Hepatobiliary surgery and nutrition · 2024Article
- Is liver resection necessary for T2 gallbladder cancer?Hepatobiliary surgery and nutrition · 2024Article
- Radical cholecystectomy without liver resection for peritoneal side early incidental gallbladder cancer.World journal of gastroenterology · 2024Article
- New trends in diagnosis and management of gallbladder carcinoma.World journal of gastrointestinal oncology · 2024Review
- Comment on "Prognostic Effect of Liver Resection in Extended Cholecystectomy for T2 Gallbladder Cancer Revisited: A Retrospective Cohort Study with Propensity-Score-Matched Analysis".Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023Article
- Comment on: Prognostic Effect of Liver Resection in Extended Cholecystectomy for T2 Gallbladder Cancer Revisited: A Retrospective Cohort Study with Propensity-Score-Matched Analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023Article
- Response to: "Comment on: Prognostic Effect of Liver Resection in Extended Cholecystectomy for T2 Gallbladder Cancer Revisited: A Retrospective Cohort Study with Propensity-Score-Matched Analysis".Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the effect of liver resection on the prognosis of T2 gallbladder cancer (GBC).
backgroundAlthough extended cholecystectomy [lymph node dissection (LND) + liver resection] is recommended for T2 GBC, recent studies have shown that liver resection does not improve survival outcomes relative to LND alone.
methodsPatients with pT2 GBC who underwent extended cholecystectomy as an initial procedure and did not reoperation after cholecystectomy at 3 tertiary referral hospitals between January 2010 and December 2020 were analyzed. Extended cholecystectomy was defined as either LND with liver resection (LND+L group) or LND only (LND group). We conducted 2:1 propensity score matching to compare the survival outcomes of the groups.
resultsOf the 197 patients enrolled, 100 patients from the LND+L group and 50 from the LND group were successfully matched. The LND+L group experienced greater estimated blood loss ( P <0.001) and a longer postoperative hospital stay ( P =0.047). There was no significant difference in the 5-year disease-free survival (DFS) of the 2 groups (82.7% vs 77.9%, respectively, P =0.376). A subgroup analysis showed that the 5-year DFS was similar in the 2 groups in both T substages (T2a: 77.8% vs 81.8%, respectively, P =0.988; T2b: 88.1% vs 71.5%, respectively, P =0.196). In a multivariable analysis, lymph node metastasis [hazard ratio (HR) 4.80, P =0.006] and perineural invasion (HR 2.61, P =0.047) were independent risk factors for DFS; liver resection was not a prognostic factor (HR 0.68, P =0.381).
conclusionsExtended cholecystectomy including LND without liver resection may be a reasonable treatment option for selected T2 GBC patients.
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