ArticleDevelopment (Cambridge, England)2023
Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.
Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- Article
- Endocrine gland growth as the developmental switch for insect diapause.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- A Peptidergic Neural System Connects the Circadian Clock to the Photoperiodic Control of Reproductive Diapause in the BugThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis ineLife · 2025Article
- Review
- Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.The European journal of neuroscience · 2025Article
- A Head-Specific Transcriptomic Study Reveals Key Regulatory Pathways for Winter Diapause in the Mosquito Culex pipiens.Archives of insect biochemistry and physiology · 2025Article
- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
- A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.Nature communications · 2024Article
- Characterization of pre-diapause phase in the northern Drosophila species D. ezoana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Regional specialization, polyploidy, and seminal fluid transcripts in theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gut-to-brain regulation ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Synaptic connectome of a neurosecretory network in thebioRxiv : the preprint server for biology · 2024Article
- Drosophila ezoana uses morning and evening oscillators to adjust its rhythmic activity to different daylengths but only the morning oscillator to measure night length for photoperiodic responses.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Integration of photoperiodic and temperature cues by the circadian clock to regulate insect seasonal adaptations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Neural mechanism of circadian clock-based photoperiodism in insects and snails.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Gut-to-brain regulation ofbioRxiv : the preprint server for biology · 2024Article
- Cyp6g2 is the major P450 epoxidase responsible for juvenile hormone biosynthesis in Drosophila melanogaster.BMC biology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Female insects can enter reproductive diapause, a state of suspended egg development, to conserve energy under adverse environments. In many insects, including the fruit fly, Drosophila melanogaster, reproductive diapause, also frequently called reproductive dormancy, is induced under low-temperature and short-day conditions by the downregulation of juvenile hormone (JH) biosynthesis in the corpus allatum (CA). In this study, we demonstrate that neuropeptide Diuretic hormone 31 (DH31) produced by brain neurons that project into the CA plays an essential role in regulating reproductive dormancy by suppressing JH biosynthesis in adult D. melanogaster. The CA expresses the gene encoding the DH31 receptor, which is required for DH31-triggered elevation of intracellular cAMP in the CA. Knocking down Dh31 in these CA-projecting neurons or DH31 receptor in the CA suppresses the decrease of JH titer, normally observed under dormancy-inducing conditions, leading to abnormal yolk accumulation in the ovaries. Our findings provide the first molecular genetic evidence demonstrating that CA-projecting peptidergic neurons play an essential role in regulating reproductive dormancy by suppressing JH biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.