ArticleVeterinary medicine and science2023
Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases.
Article in Veterinary medicine and science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Evaluation of platelet surface-associated immunoglobulin positivity and its association with hematologic findings and vector-borne pathogens in thrombocytopenic dogs.Journal of veterinary internal medicine · 2026Article
- Amegakaryocytic thrombocytopenia in a dog: Diagnostic challenges and therapeutic considerations.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Prevalence of ocular lesions in cats with anaemia and thrombocytopenia.Journal of feline medicine and surgery · 2025Article
- Prognostic factors and long-term outcome in dogs diagnosed with primary and secondary immune thrombocytopenia in Ireland.The Journal of small animal practice · 2025Article
- Evaluation of activation characteristics of a canine platelet concentrate produced by a commercial double centrifugation system.Frontiers in veterinary science · 2024Article
- Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases.Veterinary medicine and science · 2023Article
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Authors and funding
14 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagnosis of primary immune-mediated thrombocytopenia (pITP) have not been reported.
objectivesTo report the prevalence of different causes of thrombocytopenia in dogs in the United Kingdom and to investigate the utility of platelet concentration to differentiate causes of thrombocytopenia.
methodsMedical records of 762 dogs with thrombocytopenia presented to seven referral hospitals from January 2017 to December 2018 were retrospectively reviewed. Cases were assigned into the following categories: pITP, infectious diseases, neoplasia, inflammatory/other immune-mediated disorders and miscellaneous causes. The prevalence of the different categories was estimated, and platelet concentrations were compared. Receiver-operating characteristic (ROC) curves were used to investigate the utility of platelet concentration to differentiate between causes of thrombocytopenia.
resultsThe most common disease category associated with thrombocytopenia was neoplasia (27.3%), followed by miscellaneous causes (26.9%), pITP (18.8%), inflammatory/immune-mediated disorders (14.4%) and infectious diseases (12.6%). Dogs with pITP had significantly lower platelet concentrations (median 8 × 10
conclusionsSevere thrombocytopenia was highly specific for a diagnosis of pITP, which was more prevalent in this UK population of thrombocytopenic dogs compared with previous epidemiological studies. Conversely, the proportion of dogs with infectious diseases was lower than in previous reports from other locations.
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