ArticleJournal of neuroinflammation2023
Lactobacillus paracasei L9 affects disease progression in experimental autoimmune neuritis by regulating intestinal flora structure and arginine metabolism.
Article in Journal of neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Preventive effect of ulinastatin on postoperative cognitive dysfunction through modulation of the gut microbiome: evidence from short-chain fatty acids.Brain, behavior, & immunity - health · 2026Article
- Glycodeoxycholic acid synergizes with L-malic acid to upregulate the malolactic enzyme pathway to alleviate self-toxicity inApplied and environmental microbiology · 2026Article
- Multifaceted effects of proline on intestinal injury, inflammation, and lipid metabolism in piglets induced by porcine epidemic diarrhea virus.Amino acids · 2026Article
- What's in a name? Metabolite identification: challenges and pitfalls in untargeted metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2026Review
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- The Neuroprotective Effect of 4-Octyl Itaconate on Acute Period of Experimental Autoimmune Neuritis.Inflammation · 2025Article
- Gut microbiota-derived arginine metabolism mitigates intestinal ischemia-reperfusion injury.Journal of translational medicine · 2025Article
- Article
- Endoneurial immune interplay in peripheral nerve repair: insights and implications for future therapeutic interventions.Frontiers in neuroscience · 2025Review
- Immune function analysis in a pediatric patient with aFrontiers in immunology · 2025Article
- Combined Inhibition of Thrombosis byInternational journal of general medicine · 2025Article
- Lactobacillus rhamnosus ameliorates experimental autoimmune neuritis via modulation of gut microbiota and metabolites.Heliyon · 2024Article
- Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Modulation of intestinal metabolites by calorie restriction and its association with gut microbiota in a xenograft model of colorectal cancer.Discover oncology · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components are known to affect the course of autoimmune diseases. Intestinal microorganisms can be dynamically regulated through diet, and this study combines intestinal microorganisms with diseases to open up new therapeutic ideas.
methodsIn Lewis rats, a model of EAN was established with P0 peptide, Lactobacillus were used as treatment, serum T-cell ratio, inflammatory factors, sciatic neuropathological changes, and pathological inflammatory effects on intestinal mucosa were detected, and fecal metabolomics and 16 s microbiome analysis were performed to further explore the mechanism.
resultsIn the EAN rat model, Lactobacillus paracasei L9 (LP) could dynamically regulate the CD4
conclusionLP improved EAN in rats by influencing intestinal community and the lysine and proline metabolism.
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Registered trials
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