Evidence map›Paper›PMID 37217922›Full record

ArticleBMC nursing2023

Translation and validation of chinese version of MDASI immunotherapy for early-phase trials module: a cross-sectional study.

Xiaodan Wu, Jingyue Xie, Xiumei Lin, Limei Hua, Peirong Ding, Shuyue Liu, Simei Shi

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Article in BMC nursing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaodan Wu *Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.
Jingyue Xie *School of Nursing, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Xiumei LinSun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.
Limei HuaSun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.
Peirong DingSun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China. dingpr@sysucc.org.cn.
Shuyue LiuSun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China. liushy@sysucc.org.cn.
Simei ShiSun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China. shism@sysucc.org.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring immunotherapy treatment and survival, identifying symptoms requires a standardized and validated assessment tool. The aim of this study was to translate, validate and use the Chinese version of the Immunotherapy of the M.D. Anderson Symptom Inventory for Early-Phase Trials module (MDASI-Immunotherapy EPT) to assess the symptom burden of cancer patients receiving immunotherapy in China.

methodsThe MDASI-Immunotherapy EPT was translated into Chinese using Brislin's translation model and the back-translation method. In total, 312 Chinese-speaking colorectal cancer patients receiving immunotherapy were enrolled in the trial from August 2021 to July 2022 after receiving definitive diagnoses in our cancer center. The reliability and validity of the translated version was evaluated.

resultsCronbach's α values were 0.964 and 0.935 for the symptom severity and interference scales, respectively. Significant correlations were found between the MDASI-Immunotherapy EPT-C and FACT-G scores (-0.617-0.732, P < 0.001). Known-group validity was supported by significant differences in the scores of the four scales grouped by ECOG PS (all P < 0.01). The overall mean subscale scores for the core and interference subscales were 1.92 ± 1.75 and 1.46 ± 1.87, respectively. Fatigue, numbness/tingling, and disturbed sleep had the highest scores for the most serious symptoms.

conclusionThe MDASI-Immunotherapy EPT-C showed adequate reliability and validity for measuring symptoms among Chinese-speaking colorectal cancer patients receiving immunotherapy. The tool could be used in clinical practice and clinical trials to gather patients' health and quality of life data and manage their symptoms in a timely manner in the future.

Indexed as

ChineseImmunotherapyMDASIMDASI-Immunotherapy EPT-CValidation

Identifiers

PMID37217922
PMCPMC10201700

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