ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2023
Development of a HPLC system using a phase-separation multiphase flow as an eluent coupled to a silica-particle packed column.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Direct visualization of phase-separation multiphase flow in a silica bead-packed microchannel using fluorescence microscopy.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Development of a HPLC system using a phase-separation multiphase flow as an eluent: an influence of column pressure on phase separation and chromatogram at room temperature.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Development of an HPLC device with water/acetonitrile with NaCl mixed solution that induces a phase-separation multiphase flow as the eluent in the separation column.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Phase-separation multiphase flow: preliminary application to analytical chemistry.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Review
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7 authors at 2 institutions in 1 country.
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Abstract
The study reports the development of a high-performance liquid chromatography (HPLC) system in which a phase-separation multiphase flow as the eluent and a silica-particle based packed column as the separation column were combined to form the phase separation mode. Twenty-four types of mixed solutions of water/acetonitrile/ethyl acetate and water/acetonitrile were applied as eluents to the system at 20 °C. 2,6-Naphthalenedisulfonic acid (NDS) and 1-naphthol (NA) were injected as model analytes into the system. They showed separation tendency in organic solvent-rich eluents in normal-phase mode and NA was detected earlier than NDS. Subsequently, seven types of the ternary mixed solutions were examined as eluents in the HPLC system at 20 °C and 0 °C. These mixed solutions worked as a two-phase separation mixed solution, providing a phase-separation multiphase flow at 0 °C in the separation column. In the organic solvent-rich eluent, the mixture of analytes was separated at both 20 °C (normal-phase mode) and 0 °C (phase-separation mode), with NA being detected earlier than NDS. The separation at 0 °C was more efficient than at 20 °C. In the water-rich eluent, the mixture of NDS and NA was not separated at 20 °C but was separated at 0 °C (phase-separation mode), with NDS being detected earlier than NA. We also discussed the separation mechanism of phase-separation mode in HPLC together with the computer simulation for the multiphase flow in the cylindrical tube having sub-μm inner diameter.
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