Evidence map›Paper›PMID 37217558›Full record

ArticleScientific reports2023

ACCT is a fast and accessible automatic cell counting tool using machine learning for 2D image segmentation.

Theodore J Kataras, Tyler J Jang, Jeffrey Koury, Hina Singh, Dominic Fok, Marcus Kaul

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Theodore J KatarasGraduate Program of Genetics, Genomics and Bioinformatics, University of California, Riverside, Riverside, CA, 92521, USA.
Tyler J JangGraduate Program of Genetics, Genomics and Bioinformatics, University of California, Riverside, Riverside, CA, 92521, USA.
Jeffrey KourySchool of Medicine, Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, 92521, USA.
Hina SinghSchool of Medicine, Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, 92521, USA.
Dominic FokSchool of Medicine, Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, 92521, USA.
Marcus KaulGraduate Program of Genetics, Genomics and Bioinformatics, University of California, Riverside, Riverside, CA, 92521, USA. Marcus.Kaul@medsch.ucr.edu.
University of California, Riverside · US

Funding

Neuroprotection by IFN-beta in AIDSR01MH087332 · NIMH · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI KAUL, MARCUS · 2010 to 2019
$5.2M
Methamphetamine Effect on HIV PersistenceR01DA052209 · NIDA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI KAUL, MARCUS · 2020 to 2024
$3.2M
Lipocalin-2 in HIV-Associated Neuronal InjuryR01MH104131 · NIMH · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI KAUL, MARCUS · 2015 to 2019
$2.2M
Cysteinyl Leukotrienes in HIV Brain InjuryR01MH105330 · NIMH · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI KAUL, MARCUS · 2015 to 2019
$2.0M
NIDA NIH HHS R01 DA052209NIH HHS R01 MH104131NIMH NIH HHS R01 MH087332NIMH NIH HHS R01 MH104131NIMH NIH HHS R01 MH105330
6 · The paper itself

Abstract

Counting cells is a cornerstone of tracking disease progression in neuroscience. A common approach for this process is having trained researchers individually select and count cells within an image, which is not only difficult to standardize but also very time-consuming. While tools exist to automatically count cells in images, the accuracy and accessibility of such tools can be improved. Thus, we introduce a novel tool ACCT: Automatic Cell Counting with Trainable Weka Segmentation which allows for flexible automatic cell counting via object segmentation after user-driven training. ACCT is demonstrated with a comparative analysis of publicly available images of neurons and an in-house dataset of immunofluorescence-stained microglia cells. For comparison, both datasets were manually counted to demonstrate the applicability of ACCT as an accessible means to automatically quantify cells in a precise manner without the need for computing clusters or advanced data preparation.

Indexed as

Image Processing, Computer-AssistedTool Use BehaviorCell CountMachine LearningNeurons

Identifiers

PMID37217558
PMCPMC10202925
OpenAlexW4377292675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.