ArticleNature communications2023
Direct conversion of lignin to functionalized diaryl ethers via oxidative cross-coupling.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Photocatalytic Lignin Depolymerization and Cross-Coupling With Alcohols to Produce Unsymmetric Aromatic Diols.Angewandte Chemie (International ed. in English) · 2026Article
- Regioselective Synthesis of 9‑ACS omega · 2026Article
- Article
- A Robust Atomically Precise Nanocluster Catalyst for Simultaneous C-O and C-C Bond Cleavage in Lignin Models.ACS catalysis · 2025Article
- One-Step Extreme Delignification to Simultaneously Produce High-Purity Cellulose and Phenolated Lignin.ChemSusChem · 2025Article
- High enzyme promiscuity in lignin degradation mechanisms inApplied and environmental microbiology · 2025Article
- Redox-neutral photocatalytic cleavage andScience advances · 2025Article
- Tunable Transfer-Hydrodeoxygenated Upgrading of Lignin-Derived Propylphenols to Versatile Value-Added Alkane-Based Chemicals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Producing aryl halides from lignin.Nature communications · 2025Article
- Synthesis of aromatic amides from lignin and its derivatives.Nature communications · 2025Article
- Selective and mild oxidation of α-hydroxyl groups in lignin by 2-iodoxybenzoic acid.Frontiers in bioengineering and biotechnology · 2025Article
- Tandem catalysis enables chlorine-containing waste as chlorination reagents.Nature chemistry · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient valorization of lignin, a sustainable source of functionalized aromatic products, would reduce dependence on fossil-derived feedstocks. Oxidative depolymerization is frequently applied to lignin to generate phenolic monomers. However, due to the instability of phenolic intermediates, repolymerization and dearylation reactions lead to low selectivity and product yields. Here, a highly efficient strategy to extract the aromatic monomers from lignin affording functionalized diaryl ethers using oxidative cross-coupling reactions is described, which overcomes the limitations of oxidative methods and affords high-value specialty chemicals. Reaction of phenylboronic acids with lignin converts the reactive phenolic intermediates into stable diaryl ether products in near-theoretical maximum yields (92% for beech lignin and 95% for poplar lignin based on the content of β-O-4 linkages). This strategy suppresses side reactions typically encountered in oxidative depolymerization reactions of lignin and provides a new approach for the direct transformation of lignin into valuable functionalized diaryl ethers, including key intermediates in pharmaceutical and natural product synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.