ArticleNature communications2023
Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Machine Learning-Driven Radiomic Profiling of Thalamus-Amygdala Nuclei for Prediction of Postoperative Delirium After STN-DBS in Parkinson's Disease Patients: A Pilot Study.Journal of imaging informatics in medicine · 2026Article
- Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Beta bursts mediate amygdala gating of hippocampal emotional encoding.bioRxiv : the preprint server for biology · 2025Article
- Human hippocampal reactivation of amygdala encoding-related gamma patterns during aversive memory retrieval.Nature communications · 2025Article
- Structural plasticity of the contralesional subfields of hippocampus and amygdala in patients with IDH-mutant astrocytoma and oligodendroglioma.Neuroradiology · 2025Article
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- The effects of aerobic exercise on cognitive function and depressive symptom in patients with depression: a systematic review and meta-analysis of randomized controlled trials.American journal of translational research · 2025Review
- Inference of Whole Brain Electrophysiological Networks Through Multimodal Integration of Simultaneous Scalp and Intracranial EEG.Advances in neural information processing systems · 2025Article
- Whole brain alignment of spatial transcriptomics between humans and mice with BrainAlign.Nature communications · 2024Article
- Clinical Correlation of Altered Molecular Signatures in Epileptic Human Hippocampus and Amygdala.Molecular neurobiology · 2024Article
- Predictable and unpredictable deviance detection in the human hippocampus and amygdala.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Theta-Alpha Connectivity in the Hippocampal-Entorhinal Circuit Predicts Working Memory Load.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Amygdala and cognitive impairment in cerebral small vessel disease: structural, functional, and metabolic changes.Frontiers in neurology · 2024Review
- The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure.Current radiopharmaceuticals · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both the hippocampus and amygdala are involved in working memory (WM) processing. However, their specific role in WM is still an open question. Here, we simultaneously recorded intracranial EEG from the amygdala and hippocampus of epilepsy patients while performing a WM task, and compared their representation patterns during the encoding and maintenance periods. By combining multivariate representational analysis and connectivity analyses with machine learning methods, our results revealed a functional specialization of the amygdala-hippocampal circuit: The mnemonic representations in the amygdala were highly distinct and decreased from encoding to maintenance. The hippocampal representations, however, were more similar across different items but remained stable in the absence of the stimulus. WM encoding and maintenance were associated with bidirectional information flow between the amygdala and the hippocampus in low-frequency bands (1-40 Hz). Furthermore, the decoding accuracy on WM load was higher by using representational features in the amygdala during encoding and in the hippocampus during maintenance, and by using information flow from the amygdala during encoding and that from the hippocampus during maintenance, respectively. Taken together, our study reveals that WM processing is associated with functional specialization and interaction within the amygdala-hippocampus circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.