ArticleScientific reports2023
GPU accelerated digital twins of the human heart open new routes for cardiovascular research.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- The functional impact of myofiber macroscopic organization and disarray in computational models of the murine heart.PLoS computational biology · 2026Article
- Bladder Digital Twins for Neuromodulation: Current Platforms and a Roadmap to Closed-Loop Therapy.International neurourology journal · 2026Article
- A Real-Time Digital Twin for Human Cardiovascular Applications.International journal for numerical methods in biomedical engineering · 2026Article
- The Mind From Within: Visceral Roots of Human Cognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Causal inference and digital twins: a roadmap for the future of clinical trials.NPJ digital medicine · 2026Review
- A data-driven computational methodology for assessing ventricular ablation procedures.Biomechanics and modeling in mechanobiology · 2026Article
- Digital twins and digital models of the human circulatory system.Nature reviews bioengineering · 2026Article
- Toward cardiac electrophysiology digital twins with an efficient open source scalable solver on GPU clusters.Scientific reports · 2026Article
- iDT-diet: Toward Personalized Health Forecasting-An Intelligent Digital Twin Model for Diet-Influenced Biomarker Trajectories (Student Abstract).Proceedings of the ... AAAI Conference on Artificial Intelligence. AAAI Conference on Artificial Intelligence · 2026Article
- From biaxial tests to cardiac digital twins: a morphomechanics agenda for passive myocardium.Frontiers in physiology · 2026Article
- Real-time 3D cardiac tissue implementation for arrhythmia detection and management.Frontiers in bioengineering and biotechnology · 2026Article
- Development and validation of a computational tool to predict treatment outcomes in cells from high-grade serous ovarian cancer patients.Bioengineering & translational medicine · 2025Article
- A scoping review of human digital twins in healthcare applications and usage patterns.NPJ digital medicine · 2025Article
- Article
- A real-time virtual liver simulator using position based dynamics with compliant constraints for medical applications.Scientific reports · 2025Article
- Personalised Transdermal Therapy for Chronic Pain with Digital Twin Technology.Current drug targets · 2025Review
- The impact of experimental designs & system sloppiness on the personalisation process: A cardiovascular perspective.PloS one · 2025Article
- Mechano-electrical-fluid interaction left-ventricle model for numerical evaluation of aortic valve hemodynamics.Frontiers in bioengineering and biotechnology · 2025Article
- Cardiac digital twins at scale from MRI: Open tools and representative models from ~ 55000 UK Biobank participants.PloS one · 2025Article
- Multiphysics simulations reveal haemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics.The Journal of physiology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recruitment of patients for rare or complex cardiovascular diseases is a bottleneck for clinical trials and digital twins of the human heart have recently been proposed as a viable alternative. In this paper we present an unprecedented cardiovascular computer model which, relying on the latest GPU-acceleration technologies, replicates the full multi-physics dynamics of the human heart within a few hours per heartbeat. This opens the way to extensive simulation campaigns to study the response of synthetic cohorts of patients to cardiovascular disorders, novel prosthetic devices or surgical procedures. As a proof-of-concept we show the results obtained for left bundle branch block disorder and the subsequent cardiac resynchronization obtained by pacemaker implantation. The in-silico results closely match those obtained in clinical practice, confirming the reliability of the method. This innovative approach makes possible a systematic use of digital twins in cardiovascular research, thus reducing the need of real patients with their economical and ethical implications. This study is a major step towards in-silico clinical trials in the era of digital medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.