Evidence map›Paper›PMID 37217478›Full record

ArticleNature communications2023

Semantic novelty modulates neural responses to visual change across the human brain.

Maximilian Nentwich, Marcin Leszczynski, Brian E Russ, Lukas Hirsch, Noah Markowitz, Kaustubh Sapru, Charles E Schroeder, Ashesh D Mehta, Stephan Bickel, Lucas C Parra

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Maximilian NentwichDepartment of Biomedical Engineering, The City College of New York, New York, NY, USA. max.nentwich@gmail.com.ORCID 0000-0002-9306-7591
Marcin LeszczynskiDepartments of Psychiatry and Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0003-3172-4661
Brian E RussTranslational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA.ORCID 0000-0003-0320-1257
Lukas HirschDepartment of Biomedical Engineering, The City College of New York, New York, NY, USA.
Noah MarkowitzThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Kaustubh SapruDepartment of Biomedical Engineering, The City College of New York, New York, NY, USA.
Charles E SchroederDepartments of Psychiatry and Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Ashesh D MehtaThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Stephan BickelTranslational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA.
Lucas C ParraDepartment of Biomedical Engineering, The City College of New York, New York, NY, USA. parra@ccny.cuny.edu.ORCID 0000-0003-4667-816X
City College of New York · USNathan Kline Institute for Psychiatric Research · USNorthwell Health · US

Funding

Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Robert Thomas Knight · 2017 to 2026
$25.3M
Defining Neuronal Circuits and Cellular Processes Underlying Resting fMRI SignalsR01MH111439 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI MILHAM, MICHAEL PETER, SCHROEDER, CHARLES E · 2016 to 2020
$5.1M
Machine learning for risk-adjusted breast MRI screeningR01CA247910 · NCI · CITY COLLEGE OF NEW YORK · PI PARRA, LUCAS C, SUTTON, ELIZABETH J · 2021 to 2025
$3.3M
NCI NIH HHS R01 CA247910NIMH NIH HHS P50 MH109429NIMH NIH HHS R01 MH111439
6 · The paper itself

Abstract

Our continuous visual experience in daily life is dominated by change. Previous research has focused on visual change due to stimulus motion, eye movements or unfolding events, but not their combined impact across the brain, or their interactions with semantic novelty. We investigate the neural responses to these sources of novelty during film viewing. We analyzed intracranial recordings in humans across 6328 electrodes from 23 individuals. Responses associated with saccades and film cuts were dominant across the entire brain. Film cuts at semantic event boundaries were particularly effective in the temporal and medial temporal lobe. Saccades to visual targets with high visual novelty were also associated with strong neural responses. Specific locations in higher-order association areas showed selectivity to either high or low-novelty saccades. We conclude that neural activity associated with film cuts and eye movements is widespread across the brain and is modulated by semantic novelty.

Indexed as

BrainSemanticsEye MovementsHumansPhotic StimulationSaccadesTemporal Lobe

Identifiers

PMID37217478
PMCPMC10203305
OpenAlexW4377294577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.