Evidence map›Paper›PMID 37217261›Full record

ArticleRNA (New York, N.Y.)2023

Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes in

Elizabeth A Jolley, Helen Yakhnin, David C Tack, Paul Babitzke, Philip C Bevilacqua

Open access · hybridAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Optimized tRNA structure-seq reveals robust tRNA secondary structures inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. In vivo structure probing of RNA inRNA (New York, N.Y.) · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elizabeth A JolleyDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0003-3107-5403
Helen YakhninCenter for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0002-7865-7112
David C TackDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0003-0153-5288
Paul BabitzkeCenter for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0003-2481-1062
Philip C BevilacquaDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA pxb28@psu.edu pcb5@psu.edu.ORCID 0000-0001-8074-3434
Pennsylvania State University · US

Funding

Regulation of transcription elongationR01GM098399 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BABITZKE, PAUL L · 2012 to 2024
$3.6M
RNA folding and catalysis at the interface of biophysics and genomicsR35GM127064 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PHILIP C BEVILACQUA · 2018 to 2026
$3.4M
RNA thermometers and their role in regulating Bacillus subtilis gene expressionF32GM128311 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI JOLLEY, ELIZABETH · 2018 to 2021
$176k
NIGMS NIH HHS F32 GM128311NIGMS NIH HHS R01 GM098399NIGMS NIH HHS R35 GM127064
6 · The paper itself

Abstract

RNA structure regulates bacterial gene expression by several distinct mechanisms via environmental and cellular stimuli, one of which is temperature. While some genome-wide studies have focused on heat shock treatments and the subsequent transcriptomic changes, soil bacteria are less likely to experience such rapid and extreme temperature changes. Though RNA thermometers (RNATs) have been found in 5' untranslated leader regions (5' UTRs) of heat shock and virulence-associated genes, this RNA-controlled mechanism could regulate other genes as well. Using Structure-seq2 and the chemical probe dimethyl sulfate (DMS) at four growth temperatures ranging from 23°C to 42°C, we captured a dynamic response of the

Indexed as

ThermometersTranscriptome5' Untranslated RegionsBacillus subtilisGene Expression Regulation, BacterialGlycerolRNA, BacterialTemperature5' Untranslated RegionsGlycerolRNA, Bacterialglycerol permeaseRNA–proteinRNA thermometersStructure-seq

Identifiers

PMID37217261
PMCPMC10573289
OpenAlexW4377237694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.