Evidence map›Paper›PMID 37217075›Full record

ArticleBrain stimulation

Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders.

Frederick L Hitti, Alik S Widge, Patricio Riva-Posse, Donald A Malone, Michael S Okun, Maryam M Shanechi, Kelly D Foote, Sarah H Lisanby, Elizabeth Ankudowich, Srinivas Chivukula and 23 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Contemporary Ethical Considerations in Psychiatric Neurosurgery.Stereotactic and functional neurosurgery · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Neurosurgical neuromodulation therapy for psychiatric disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 2 countries.

Frederick L HittiDepartment of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: Frederick.Hitti@utsouthwestern.edu.
Alik S WidgeDepartment of Psychiatry and Behavioral Sciences, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Patricio Riva-PosseDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Donald A MaloneDepartment of Psychiatry, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
Michael S OkunDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, Gainesville, FL, USA.
Maryam M ShanechiDepartments of Electrical and Computer Engineering and Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Kelly D FooteDepartment of Neurosurgery, Norman Fixel Institute for Neurological Diseases, Gainesville, FL, USA.
Sarah H LisanbyExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, USA.
Elizabeth AnkudowichDivision of Translational Research, National Institute of Mental Health, Bethesda, MD, USA.
Srinivas ChivukulaDepartment of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Edward F ChangDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Aysegul GunduzDepartment of Biomedical Engineering and Fixel Institute for Neurological Disorders, University of Florida, Gainesville, FL, USA.
Clement HamaniSunnybrook Research Institute, Hurvitz Brain Sciences Centre, Harquail Centre for Neuromodulation, Division of Neurosurgery, University of Toronto, Toronto, Canada.
Ashley FeinsingerDepartment of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Cynthia S KubuDepartment of Neurology, Cleveland Clinic and Case Western Reserve University, School of Medicine, Cleveland, OH, USA.
Winston ChiongDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Jennifer A ChandlerFaculty of Law, University of Ottawa, Ottawa, ON, USA; Affiliate Investigator, Bruyère Research Institute, Ottawa, ON, USA.
Rafael CarbunaruNeuromodulation Division, Boston Scientific, Valencia, CA, USA.
Binith CheeranNeuromodulation Division, Abbott, Austin, TX, USA.
Robert S RaikeGlobal Research Organization, Medtronic Inc. Neuromodulation, Minneapolis, MN, USA.
Rachel A DavisDepartments of Psychiatry and Neurosurgery, University of Colorado Anschutz, Aurora, CO, USA.
Casey H HalpernDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; The Cpl Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Nora Vanegas-ArroyaveDepartment of Neurology, Baylor College of Medicine, Houston, TX, USA.
Dejan MarkovicDepartment of Electrical Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Sarah K BickDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Cameron C McIntyreDepartments of Biomedical Engineering and Neurosurgery, Duke University, Durham, NC, USA.
R Mark RichardsonDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Brian H KopellDepartment of Neurosurgery, Center for Neuromodulation, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jennifer A SweetDepartment of Neurosurgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Wayne K GoodmanDepartment of Psychiatry and Behavior Sciences, Baylor College of Medicine, Houston, TX, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Nader PouratianDepartment of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Baylor College of Medicine · USMassachusetts General Hospital · USNational Institute of Mental Health · USThe University of Texas Southwestern Medical Center · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Florida · USAbbott (United States) · USBoston Scientific (United States) · USBruyère · CACleveland Clinic · USCleveland Clinic Lerner College of Medicine · USDuke University · USEmory University · USIcahn School of Medicine at Mount Sinai · USMedtronic (United States) · USNeurological Surgery · USPhiladelphia VA Medical Center · USSouthwestern Medical Center · USSunnybrook Health Science Centre · CA

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
Transitioning Early Career Neurosurgeons to Scientific IndependenceK12NS080223 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ESKANDAR, EMAD N · 2012 to 2022
$9.2M
Deep brain stimulation for depression using directional current steering an individualized network targetingUH3NS103549 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOODMAN, WAYNE K, POURATIAN, NADER · 2017 to 2025
$8.7M
Early Feasibility Clinical Trial of a Visual Cortical ProsthesisUH3NS103442 · NINDS · SECOND SIGHT MEDICAL PRODUCTS, INC. · PI GREENBERG, ROBERT JAY, PATEL, UDAY KIRIT · 2018 to 2023
$6.8M
Data Archive for the Brain Initiative (DABI)R24MH114796 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUNCAN, DOMINIQUE, POURATIAN, NADER · 2018 to 2023
$6.2M
The Pathophysiology of Network Synchrony in Parkinson's DiseaseR01NS097782 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI NADER POURATIAN · 2016 to 2026
$5.2M
Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain StimulationUH3NS119844 · NINDS · UNIVERSITY OF FLORIDA · PI BUTSON, CHRISTOPHER R, GUNDUZ, AYSEGUL · 2021 to 2025
$5.0M
Web-based Automated Imaging Differentiation of ParkinsonismU01NS119562 · NINDS · UNIVERSITY OF FLORIDA · PI BARMPOUTIS, ANGELOS, OKUN, MICHAEL S · 2021 to 2025
$4.8M
The role of pericytes in white matter diseaseR01NS100459 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2016 to 2020
$3.6M
Spatiotemporal dynamics of the human emotion networkR01MH122431 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, EDWARD, STURM, VIRGINIA EMILY · 2021 to 2025
$3.4M
Deep Brain Stimulation of the Subgenual Cingulate Cortex for the Treatment of Medically Refractory Chronic Low Back PainUH3NS113661 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AUSAF BARI, NADER POURATIAN · 2019 to 2026
$2.9M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
Intramural NIH HHS ZIA MH002955NIGMS NIH HHS R01 GM135420NIMH NIH HHS R01 MH114853NIMH NIH HHS R01 MH122431NIMH NIH HHS R24 MH114796NIMH NIH HHS RF1 MH121373NIMH NIH HHS RF1 MH123407NINDS NIH HHS K12 NS080223NINDS NIH HHS R01 NS096008NINDS NIH HHS R01 NS097782NINDS NIH HHS R01 NS100459NINDS NIH HHS R25 NS108939NINDS NIH HHS RC1 NS068086NINDS NIH HHS U01 NS119562NINDS NIH HHS UH3 NS095553NINDS NIH HHS UH3 NS103442NINDS NIH HHS UH3 NS103549NINDS NIH HHS UH3 NS113661NINDS NIH HHS UH3 NS119844NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

objectiveDespite advances in the treatment of psychiatric diseases, currently available therapies do not provide sufficient and durable relief for as many as 30-40% of patients. Neuromodulation, including deep brain stimulation (DBS), has emerged as a potential therapy for persistent disabling disease, however it has not yet gained widespread adoption. In 2016, the American Society for Stereotactic and Functional Neurosurgery (ASSFN) convened a meeting with leaders in the field to discuss a roadmap for the path forward. A follow-up meeting in 2022 aimed to review the current state of the field and to identify critical barriers and milestones for progress.

designThe ASSFN convened a meeting on June 3, 2022 in Atlanta, Georgia and included leaders from the fields of neurology, neurosurgery, and psychiatry along with colleagues from industry, government, ethics, and law. The goal was to review the current state of the field, assess for advances or setbacks in the interim six years, and suggest a future path forward. The participants focused on five areas of interest: interdisciplinary engagement, regulatory pathways and trial design, disease biomarkers, ethics of psychiatric surgery, and resource allocation/prioritization. The proceedings are summarized here.

conclusionThe field of surgical psychiatry has made significant progress since our last expert meeting. Although weakness and threats to the development of novel surgical therapies exist, the identified strengths and opportunities promise to move the field through methodically rigorous and biologically-based approaches. The experts agree that ethics, law, patient engagement, and multidisciplinary teams will be critical to any potential growth in this area.

Indexed as

Deep Brain StimulationMental DisordersNeurosurgeryPsychosurgeryHumansNeurosurgical ProceduresUnited StatesDeep brain stimulation (DBS)NeuromodulationObsessive compulsive disorderTourette syndromeTreatment resistant depression

Identifiers

PMID37217075
PMCPMC11189296
OpenAlexW4377157557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.