Evidence map›Paper›PMID 37216955›Full record

ReviewThe Lancet. Respiratory medicine2023

Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, and approaches to clinical care and rehabilitation.

Sally J Singh, Molly M Baldwin, Enya Daynes, Rachael A Evans, Neil J Greening, R Gisli Jenkins, Nazir I Lone, Hamish McAuley, Puja Mehta, Joseph Newman and 5 more

Open access · bronzeAbstract readReview
In one paragraph

Review in The Lancet. Respiratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 3 pooled it
34.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 166 citations in OpenAlex.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Sally J SinghInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK. Electronic address: ss1119@le.ac.uk.
Molly M BaldwinInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK.
Enya DaynesInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK.
Rachael A EvansInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK.
Neil J GreeningInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK.
R Gisli JenkinsImperial College London National Heart and Lung Institute, London, UK.
Nazir I LoneDepartment of Anaesthesia, Critical Care and Pain Medicine, Usher Institute, The University of Edinburgh, Edinburgh, UK.
Hamish McAuleyInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK.
Puja MehtaCentre for Inflammation and Tissue Repair, Division of Medicine, University College London, London, UK.
Joseph NewmanRoyal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Petr NovotnyInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK.
David J F SmithRoyal Brompton and Harefield Hospitals, London, UK.
Stefan StanelManchester University NHS Foundation Trust, Manchester, UK.
Mark ToshnerNIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Christopher E BrightlingInstitute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory and Infectious Diseases, Leicester, UK.
NIHR Leicester Biomedical Research Centre · GBHarefield Hospital · GBImperial College London · GBManchester University NHS Foundation Trust · GBNIHR Cambridge Biomedical Research CentrePapworth Hospital NHS Foundation Trust · GBUniversity College London · GBUniversity of Edinburgh · GB

Funding

Department of HealthMedical Research Council MR/W006111/1
6 · The paper itself

Abstract

Although the exact prevalence of post-COVID-19 condition (also known as long COVID) is unknown, more than a third of patients with COVID-19 develop symptoms that persist for more than 3 months after SARS-CoV-2 infection. These sequelae are highly heterogeneous in nature and adversely affect multiple biological systems, although breathlessness is a frequently cited symptom. Specific pulmonary sequelae, including pulmonary fibrosis and thromboembolic disease, need careful assessment and might require particular investigations and treatments. COVID-19 outcomes in people with pre-existing respiratory conditions vary according to the nature and severity of the respiratory disease and how well it is controlled. Extrapulmonary complications such as reduced exercise tolerance and frailty might contribute to breathlessness in post-COVID-19 condition. Non-pharmacological therapeutic options, including adapted pulmonary rehabilitation programmes and physiotherapy techniques for breathing management, might help to attenuate breathlessness in people with post-COVID-19 condition. Further research is needed to understand the origins and course of respiratory symptoms and to develop effective therapeutic and rehabilitative strategies.

Indexed as

COVID-19Pulmonary FibrosisDisease ProgressionDyspneaHumansPost-Acute COVID-19 SyndromeSARS-CoV-2

Identifiers

PMID37216955
PMCPMC10198676
OpenAlexW4377088914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.