Evidence map›Paper›PMID 37216676›Full record

ArticleJournal of natural products2023

The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of

Yulin Ren, Elizabeth N Kaweesa, Lei Tian, Sijin Wu, Kongmany Sydara, Mouachanh Xayvue, Curtis E Moore, Djaja D Soejarto, Xiaolin Cheng, Jianhua Yu and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of natural products, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Cytotoxic and Noncytotoxic Steroidal Constituents ofJournal of natural products · 2025
    Article
  4. Digoxin and its NaBioorganic & medicinal chemistry · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Yulin RenDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0003-3667-1466
Elizabeth N KaweesaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-9799-646X
Lei TianCity of Hope National Medical Center, Duarte, California 91010, United States.
Sijin WuShenzhen Jingtai Technology Co., Shenzhen 518000, Guangdong Province, People's Republic of China.
Kongmany SydaraInstitute of Traditional Medicine, Ministry of Health, Vientiane XJ68+V3P, Lao People's Democratic Republic.
Mouachanh XayvueInstitute of Traditional Medicine, Ministry of Health, Vientiane XJ68+V3P, Lao People's Democratic Republic.
Curtis E MooreX-ray Crystallography Facility, Department of Chemistry and Biochemistry, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-3311-7155
Djaja D SoejartoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Xiaolin ChengDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-7396-3225
Jianhua YuCity of Hope National Medical Center, Duarte, California 91010, United States.
Joanna E BurdetteDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-7271-6847
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-6647-8707
The Ohio State University · USCity Of Hope National Medical Center · USMinistry of Health · LAUniversity of Illinois Chicago · USField Museum of Natural History · US

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI Joanna E Burdette · 2007 to 2026
$27.2M
IRACDA at University of Illinois at ChicagoK12GM139186 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURDETTE, JOANNA E, NONN, LARISA · 2020 to 2024
$3.6M
NCI NIH HHS P01 CA125066NIGMS NIH HHS K12 GM139186
6 · The paper itself

Abstract

A cardiac glycoside epoxide, (-)-cryptanoside A (

Indexed as

Antineoplastic AgentsCardiac GlycosidesOvarian NeoplasmsApoptosisCell Line, TumorCryptolepisDigoxinFemaleHumansMolecular Docking SimulationSodium-Potassium-Exchanging ATPaseAntineoplastic AgentsCardiac GlycosidesDigoxinSodium-Potassium-Exchanging ATPase

Identifiers

PMID37216676
PMCPMC10331789
OpenAlexW4377232386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.