Evidence map›Paper›PMID 37216549›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

TRPV1 activation in human Langerhans cells and T cells inhibits mucosal HIV-1 infection via CGRP-dependent and independent mechanisms.

Jammy Mariotton, Emmanuel Cohen, Aiwei Zhu, Cédric Auffray, Caio César Barbosa Bomfim, Nicolas Barry Delongchamps, Marc Zerbib, Morgane Bomsel, Yonatan Ganor

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Channels (Austin, Tex.) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Roles of endothelial cells during infection.Current opinion in immunology · 2025
    Review
  7. Review
  8. Febrile temperature-regulated TRPV1 in CD4Journal of neuroinflammation · 2025
    Article
  9. Article
  10. Article
  11. Interleukin-1α links peripheral CaScientific reports · 2024
    Article
  12. T cells at the interface of neuroimmune communication.The Journal of allergy and clinical immunology · 2024
    Review
  13. Interleukin-1α links peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jammy MariottonLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of infection Immunity and Inflammation, Universiteé Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR8104, F-75014 Paris, France.
Emmanuel CohenLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of infection Immunity and Inflammation, Universiteé Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR8104, F-75014 Paris, France.
Aiwei ZhuLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of infection Immunity and Inflammation, Universiteé Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR8104, F-75014 Paris, France.
Cédric AuffrayLaboratory of Regulation of T Cell Effector Functions, Department of infection Immunity and Inflammation, Universiteé Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR8104, F-75014 Paris, France.ORCID 0000-0002-1012-0132
Caio César Barbosa BomfimLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of infection Immunity and Inflammation, Universiteé Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR8104, F-75014 Paris, France.ORCID 0000-0003-1998-9237
Nicolas Barry DelongchampsUrology Service, Groupe Hospitalier (GH) Cochin-St Vincent de Paul, F-75014 Paris, France.
Marc ZerbibUrology Service, Groupe Hospitalier (GH) Cochin-St Vincent de Paul, F-75014 Paris, France.
Morgane BomselLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of infection Immunity and Inflammation, Universiteé Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR8104, F-75014 Paris, France.ORCID 0000-0002-9577-7474
Yonatan GanorLaboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of infection Immunity and Inflammation, Universiteé Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR8104, F-75014 Paris, France.
Centre National de la Recherche Scientifique · FRGroupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upon its mucosal transmission, HIV type 1 (HIV-1) rapidly targets genital antigen-presenting Langerhans cells (LCs), which subsequently transfer infectious virus to CD4

Indexed as

Calcitonin Gene-Related PeptideHIV InfectionsCapsaicinHumansLangerhans CellsMucous MembranePainT-LymphocytesTRPV Cation ChannelsCalcitonin Gene-Related PeptideCapsaicinTRPV1 protein, humanTRPV Cation ChannelsCGRP, calcitonin gene-related peptideCP, capsaicinHIV-1, human immunodeficiency virus type 1LCs, Langerhans cells, T-cellsTRPV1, transient receptor potential vanilloid 1

Identifiers

PMID37216549
PMCPMC10235960
OpenAlexW4377290745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.