Evidence map›Paper›PMID 37216519›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Structure-function study of a Ca

Simon Stael, Igor Sabljić, Dominique Audenaert, Thilde Andersson, Liana Tsiatsiani, Robert P Kumpf, Andreu Vidal-Albalat, Cecilia Lindgren, Dominique Vercammen, Silke Jacques and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 3 countries.

Simon StaelDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0001-8322-0428
Igor SabljićDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 75007 Uppsala, Sweden.ORCID 0000-0001-9044-2678
Dominique AudenaertVIB Screening Core, VIB, 9052 Ghent, Belgium.
Thilde AnderssonDepartment of Chemistry, Umeå University, 90187 Umeå, Sweden.ORCID 0009-0003-7727-1968
Liana TsiatsianiDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0003-1214-0329
Robert P KumpfORCID 0000-0002-4046-6935
Andreu Vidal-AlbalatDepartment of Chemistry, Umeå University, 90187 Umeå, Sweden.
Cecilia LindgrenDepartment of Chemistry, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0002-7907-9318
Dominique VercammenDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0002-5497-0438
Silke JacquesDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Long NguyenVIB Screening Core, VIB, 9052 Ghent, Belgium.
Maria NjoDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Álvaro D Fernández-FernándezDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0003-4770-9757
Tine BeunensDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Evy TimmermanDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.
Kris GevaertDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0002-4237-0283
Marc Van MontaguDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0003-4711-5131
Jerry StåhlbergDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 75007 Uppsala, Sweden.ORCID 0000-0003-4059-8580
Peter V BozhkovDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 75007 Uppsala, Sweden.ORCID 0000-0002-8819-3884
Anna LinussonDepartment of Chemistry, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0003-0063-8912
Tom BeeckmanDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Frank Van BreusegemDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0002-3147-0860
University of Hohenheim · DEGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metacaspases are part of an evolutionarily broad family of multifunctional cysteine proteases, involved in disease and normal development. As the structure-function relationship of metacaspases remains poorly understood, we solved the X-ray crystal structure of an

Indexed as

ArabidopsisCaspasesApoptosisDNA-Binding ProteinsHumansMolecular Docking SimulationCaspasesDNA-Binding ProteinsAtMCA-IIf crystal structurecysteine proteaselateral root developmentmetacaspasesmall chemical inhibitor

Identifiers

PMID37216519
PMCPMC10235996
OpenAlexW4377291331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.