Evidence map›Paper›PMID 37216508›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Dimer-assisted mechanism of (un)saturated fatty acid decarboxylation for alkene production.

Leticia L Rade, Wesley C Generoso, Suman Das, Amanda S Souza, Rodrigo L Silveira, Mayara C Avila, Plinio S Vieira, Renan Y Miyamoto, Ana B B Lima, Juliana A Aricetti and 7 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Leticia L RadeBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Wesley C GenerosoBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.ORCID 0000-0002-5923-1458
Suman DasDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695-7622.
Amanda S SouzaBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Rodrigo L SilveiraInstitute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-594, Brazil.ORCID 0000-0001-9515-3082
Mayara C AvilaBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Plinio S VieiraBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.ORCID 0000-0001-9960-7176
Renan Y MiyamotoBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Ana B B LimaInstitute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-594, Brazil.ORCID 0009-0005-6497-3156
Juliana A AricettiBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Ricardo R de MeloBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Natalia MilanBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Gabriela F PersinotiBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.ORCID 0000-0002-0975-7283
Antonio M F L J BonomiBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Mario T MurakamiBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Thomas M MakrisDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695-7622.ORCID 0000-0001-7927-620X
Leticia M ZanphorlinBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, Brazil.
Brazilian Center for Research in Energy and Materials · BRNorth Carolina State University · USUniversidade Federal do Rio de Janeiro · BR

Funding

Divergence of Carboxylate-Bridged Diiron Enzymes for Natural Product BiosynthesisR01GM135315 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MAKRIS, THOMAS M · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM135315
6 · The paper itself

Abstract

The enzymatic decarboxylation of fatty acids (FAs) represents an advance toward the development of biological routes to produce drop-in hydrocarbons. The current mechanism for the P450-catalyzed decarboxylation has been largely established from the bacterial cytochrome P450 OleT

Indexed as

AlkenesFatty AcidsCytochrome P-450 Enzyme SystemDecarboxylationOxidation-ReductionAlkenesCytochrome P-450 Enzyme SystemFatty Acidsalkene productionCYP152 peroxygenasedecarboxylation activitymolecular mechanismrenewable hydrocarbons

Identifiers

PMID37216508
PMCPMC10235961
OpenAlexW4377292839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.