Evidence map›Paper›PMID 37216489›Full record

ArticleJournal of medicinal chemistry2023

Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides.

Ho Shin Kim, Diana Ortiz, Tara Man Kadayat, Corinne M Fargo, Jared T Hammill, Yizhe Chen, Amy L Rice, Kristin L Begley, Gaurav Shoeran, William Pistel and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ho Shin KimDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Diana OrtizDepartment of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.
Tara Man KadayatDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Corinne M FargoDepartment of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.ORCID 0000-0003-0012-9579
Jared T HammillDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Yizhe ChenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Amy L RiceDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Kristin L BegleyDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Gaurav ShoeranDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
William PistelDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Phillip A YatesDepartment of Chemical Physiology & Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 United States.
Marco A SanchezDepartment of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.
Scott M LandfearDepartment of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.
R Kiplin GuyDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.ORCID 0000-0002-9638-2060
University of Kentucky · USOregon Health & Science University · US

Funding

Bruker AVANCE NEO 600 MHz High-Performance Digital NMR SpectrometerS10OD028690 · OD · UNIVERSITY OF KENTUCKY · PI GARNEAU-TSODIKOVA, SYLVIE · 2020 to 2020
$1.4M
Development of Novel Therapeutics for LeishmaniasisR33AI127591 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI GUY, RODNEY KIPLIN, LANDFEAR, SCOTT M · 2019 to 2021
$1.4M
NIAID NIH HHS R33 AI127591NIH HHS S10 OD028690
6 · The paper itself

Abstract

Leishmaniasis, a neglected tropical disease caused by

Indexed as

Antiprotozoal AgentsLeishmaniaLeishmaniasisAnimalsBenzamidesHumansMiceAntiprotozoal AgentsbenzamideBenzamides

Identifiers

PMID37216489
PMCPMC10259451
OpenAlexW4377233181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.