Evidence map›Paper›PMID 37216437›Full record

ArticleCirculation2023

Subepicardial Cardiomyopathy: A Disease Underlying J-Wave Syndromes and Idiopathic Ventricular Fibrillation.

Chris Miles, Bastiaan J Boukens, Chiara Scrocco, Arthur A M Wilde, Koonlawee Nademanee, Michel Haissaguerre, Ruben Coronel, Elijah R Behr

Open access · hybridAbstract read
In one paragraph

Article in Circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Quantitative Histological Insights Into Sudden Arrhythmic Death Syndrome: Findings From a Forensic Autopsy Cohort.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Article
  4. Computer-aided characterization of the arrhythmogenic substrate after myocardial infarction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Predictive value of Shanghai score system in patients with drug-induced type 1 Brugada electrocardiographic pattern.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  9. Article
  10. Article
  11. Accumulating evidence for epicardial ablation in malignant forms of Brugada syndrome: summary of two randomized clinical trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  12. Review
  13. Brugada syndrome.Nature reviews. Disease primers · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Chris MilesCardiovascular Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust and Molecular and Clinical Sciences Institute, St. George's, University of London, UK (C.M., C.S., E.R.B.).ORCID 0000-0002-8192-5739
Bastiaan J BoukensDepartment of Medical Biology, University of Amsterdam, the Netherlands (B.J.B.).
Chiara ScroccoCardiovascular Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust and Molecular and Clinical Sciences Institute, St. George's, University of London, UK (C.M., C.S., E.R.B.).ORCID 0000-0001-7739-4042
Arthur A M WildeAmsterdam UMC, University of Amsterdam, Department of Cardiology, the Netherlands (A.A.M.W.).ORCID 0000-0002-0528-0852
Koonlawee NademaneeCenter of Excellence in Arrhythmia Research Chulalongkorn University, Department of Medicine, Chulalongkorn University, Thailand (K.N.).ORCID 0000-0001-8139-0343
Michel HaissaguerreEuropean Reference Network for rare, low-prevalence, and complex diseases of the heart: ERN GUARD-Heart (A.A.M.W., M.H.).ORCID 0000-0001-7644-6146
Ruben Coronel *Department of Experimental Cardiology, Amsterdam University Medical Centers, Cardiovascular Science, the Netherlands (R.C.).
Elijah R Behr *Cardiovascular Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust and Molecular and Clinical Sciences Institute, St. George's, University of London, UK (C.M., C.S., E.R.B.).ORCID 0000-0002-8731-2853
St George’s University Hospitals NHS Foundation Trust · GBAmsterdam University Medical Centers · NLCentre Hospitalier Universitaire de Bordeaux · FRChulalongkorn University · THHeart Rhythm Society · USMaastricht University Medical Centre · NL

Funding

British Heart Foundation FS/18/28/33549British Heart Foundation SP/20/4/35124
6 · The paper itself

Abstract

Brugada syndrome (BrS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (iVF) have long been considered primary electrical disorders associated with malignant ventricular arrhythmia and sudden cardiac death. However, recent studies have revealed the presence of subtle microstructural abnormalities of the extracellular matrix in some cases of BrS, ERS, and iVF, particularly within right ventricular subepicardial myocardium. Substrate-based ablation within this region has been shown to ameliorate the electrocardiographic phenotype and to reduce arrhythmia frequency in BrS. Patients with ERS and iVF may also exhibit low-voltage and fractionated electrograms in the ventricular subepicardial myocardium, which can be treated with ablation. A significant proportion of patients with BrS and ERS, as well as some iVF survivors, harbor pathogenic variants in the voltage-gated sodium channel gene,

Indexed as

Brugada SyndromeCardiomyopathiesArrhythmias, CardiacElectrocardiographyHumansVentricular Fibrillationarrhythmogenic cardiomyopathiesBrugada syndromeventricular fibrillation

Identifiers

PMID37216437
PMCPMC11073566
OpenAlexW4377232843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.