ArticlePLoS pathogens2023
A novel partitivirus orchestrates conidiation, stress response, pathogenicity, and secondary metabolism of the entomopathogenic fungus Metarhizium majus.
Article in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- The chitinolytic enzymes from the entomopathogenic fungusFrontiers in fungal biology · 2026Review
- Accumulation of the spontaneous and random mutations is causative of fungal culture degeneration.Fundamental research · 2026Article
- Detection of dsRNA in Soil-Derived Ascomycetes and Characterization of Cladosporium cladosporioides Partitivirus 1 Isolate IPBL11.Mycobiology · 2026Article
- Mycoviruses in Entomopathogenic Fungi.Viruses · 2025Review
- Genomic characterisation of a novel unirnavirus isolated from the entomopathogenic fungus Metarhizium acridum.Archives of virology · 2025Article
- A mycovirus enhances fitness of an insect pathogenic fungus and potentially modulates virulence through interactions between viral and host proteins.PLoS pathogens · 2025Article
- Molecular characterization of four novel mycoviruses in entomopathogenic and nematophagous fungi.Virology journal · 2025Article
- Identification and complete genome sequences of two novel double-stranded RNA viruses infecting the basal fungus Conidiobolus lii.Archives of virology · 2025Article
- Characterization of the mycovirus Aspergillus sulphureus partitivirus 1.Archives of virology · 2025Article
- Genomic characterization of a novel gammapartitivirus infecting the phytopathogenic fungus Colletotrichum cliviicola.Archives of virology · 2025Article
- Insect hypovirulence-associated mycovirus confers entomopathogenic fungi with enhanced resistance against phytopathogens.Virulence · 2024Article
- Molecular characterization of a novel gammapartitivirus infecting the fungus Nigrospora oryzae.Archives of virology · 2024Article
- Identification of a novel member of the genus Laulavirus (family Phenuiviridae) from the entomopathogenic ascomycete fungus Cordyceps javanica.Archives of virology · 2024Article
- Transfection of entomopathogenicProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Hypothetical protein MAA_07646 is required for stress resistance and pathogenicity in Metarhizium robertsii.World journal of microbiology & biotechnology · 2024Article
- Molecular Characterization of the First Partitivirus from a Causal Agent ofJournal of fungi (Basel, Switzerland) · 2024Article
- A novel partitivirus conferring hypovirulence by affecting vesicle transport in the fungusmBio · 2024Article
- Cross-species transmission of a novel bisegmented orfanplasmovirus in the phytopathogenic fungusFrontiers in microbiology · 2024Article
- Hypovirulence-associated mycovirus epidemics cause pathogenicity degeneration of Beauveria bassiana in the field.Virology journal · 2023Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoviruses are widely present in all major groups of fungi but those in entomopathogenic Metarhizium spp. remain understudied. In this investigation, a novel double-stranded (ds) RNA virus is isolated from Metarhizium majus and named Metarhizium majus partitivirus 1 (MmPV1). The complete genome sequence of MmPV1 comprises two monocistronic dsRNA segments (dsRNA 1 and dsRNA 2), which encode an RNA-dependent RNA polymerase (RdRp) and a capsid protein (CP), respectively. MmPV1 is classified as a new member of the genus Gammapartitivirus in the family Partitiviridae based on phylogenetic analysis. As compared to an MmPV1-free strain, two isogenic MmPV1-infected single-spore isolates were compromised in terms of conidiation, and tolerance to heat shock and UV-B irradiation, while these phenotypes were accompanied by transcriptional suppression of multiple genes involved in conidiation, heat shock response and DNA damage repair. MmPV1 attenuated fungal virulence since infection resulted in reduced conidiation, hydrophobicity, adhesion, and cuticular penetration. Additionally, secondary metabolites were significantly altered by MmPV1 infection, including reduced production of triterpenoids, and metarhizins A and B, and increased production of nitrogen and phosphorus compounds. However, expression of individual MmPV1 proteins in M. majus had no impact on the host phenotype, suggesting insubstantive links between defective phenotypes and a single viral protein. These findings indicate that MmPV1 infection decreases M. majus fitness to its environment and its insect-pathogenic lifestyle and environment through the orchestration of the host conidiation, stress tolerance, pathogenicity, and secondary metabolism.
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