Evidence map›Paper›PMID 37216270›Full record

ArticleACS sensors2023

Air-Bubble-Insensitive Microfluidic Lactate Biosensor for Continuous Monitoring of Lactate in Sweat.

Isao Shitanda, Yuro Ozone, Yuki Morishita, Hiroyuki Matsui, Noya Loew, Masahiro Motosuke, Takahiro Mukaimoto, Momoko Kobayashi, Taketo Mitsuhara, Yamato Sugita and 6 more

Abstract read
In one paragraph

Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  8. Development of a sensor-compatible vascular microphysiological system for metabolic monitoring during drug-induced endothelial injury.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Isao ShitandaDepartment of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.ORCID 0000-0001-9751-016X
Yuro OzoneDepartment of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Yuki MorishitaDepartment of Mechanical Engineering, Faculty of Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.
Hiroyuki MatsuiResearch Center for Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa 992-8510, Yamagata, Japan.ORCID 0000-0003-1956-9603
Noya LoewDepartment of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Masahiro MotosukeResearch Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.ORCID 0000-0001-6961-0382
Takahiro MukaimotoResearch Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Momoko KobayashiDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Taketo MitsuharaDepartment of Globe Fire Science and Technology, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Yamato SugitaDepartment of Globe Fire Science and Technology, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Kensuke MatsuoDepartment of Globe Fire Science and Technology, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Shinya YanagitaResearch Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Tatsunori SuzukiDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.
Tsutomu MikawaRIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Kanagawa, Japan.ORCID 0000-0003-2325-5084
Hikari WatanabeDepartment of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.ORCID 0000-0002-1547-7042
Masayuki ItagakiDepartment of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to develop a lactate sensor with a microchannel that overcomes the issue of air bubbles interfering with the measurement of lactate levels in sweat and to evaluate its potential for continuous monitoring of lactate in sweat. To achieve continuous monitoring of lactate, a microchannel was used to supply and drain sweat from the electrodes of the lactate sensor. A lactate sensor was then developed with a microchannel that has an area specifically designed to trap air bubbles and prevent them from contacting the electrode. The sensor was evaluated by a person while exercising to test its effectiveness in monitoring lactate in sweat and its correlation with blood lactate levels. Furthermore, the lactate sensor with a microchannel in this study can be worn on the body for a long time and is expected to be used for the continuous monitoring of lactate in sweat. The developed lactate sensor with a microchannel effectively prevented air bubbles from interfering with the measurement of lactate levels in sweat. The sensor showed a concentration correlation ranging from 1 to 50 mM and demonstrated a correlation between lactate in sweat and blood. Additionally, the lactate sensor with a microchannel in this study can be worn on the body for an extended period and is expected to be useful for the continuous monitoring of lactate in sweat, particularly in the fields of medicine and sports.

Indexed as

Biosensing TechniquesLactic AcidElectrodesHumansMicrofluidicsSweatLactic Acidcontinuous monitoringlactate biosensormicrofluidicssweat analysiswearable sensor

Identifiers

PMID37216270
PMCPMC10294251

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.