Evidence map›Paper›PMID 37216102›Full record

ArticleiScience2023

Mbnl2 loss alters novel context processing and impairs object recognition memory.

Abinash Khandelwal, Jesse Cushman, Jongkyu Choi, Irina Zhuravka, Abha Rajbhandari, Parvin Valiulahi, Xiandu Li, Chenyu Zhou, Lucio Comai, Sita Reddy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Abinash KhandelwalDepartment of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jesse CushmanUCLA Behavioral Testing Core, University of California Los Angeles, Los Angeles, CA 90095-1563, USA.
Jongkyu ChoiDepartment of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Irina ZhuravkaUCLA Behavioral Testing Core, University of California Los Angeles, Los Angeles, CA 90095-1563, USA.
Abha RajbhandariUCLA Behavioral Testing Core, University of California Los Angeles, Los Angeles, CA 90095-1563, USA.
Parvin ValiulahiDepartment of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Xiandu Li. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Chenyu ZhouDepartment of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Lucio Comai. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Sita ReddyDepartment of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
University of Southern California · USUniversity of California, Los Angeles · US

Funding

Neurobehavioral Core LaboratoryZICES103330 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUSHMAN, JESSE · 2018 to 2025
$13.3M
Mechanism of Small Molecule Mediated Rescue of Mytonic DystrophyR01NS080547 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI REDDY, SITA · 2013 to 2017
$2.2M
NINDS NIH HHS R01 NS080547
6 · The paper itself

Abstract

Patients with myotonic dystrophy type I (DM1) demonstrate visuospatial dysfunction and impaired performance in tasks requiring recognition or memory of figures and objects. In DM1, CUG expansion RNAs inactivate the muscleblind-like (MBNL) proteins. We show that constitutive Mbnl2 inactivation in

Indexed as

Biological sciencesMolecular biologyMolecular mechanism of gene regulationNeuroscienceTranscriptomics

Identifiers

PMID37216102
PMCPMC10193234
OpenAlexW4366814597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.