Evidence map›Paper›PMID 37216093›Full record

ArticleiScience2023

Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress.

Evgenia Fadzeyeva, Cassandra A A Locatelli, Natasha A Trzaskalski, My-Anh Nguyen, Megan E Capozzi, Branka Vulesevic, Nadya M Morrow, Peyman Ghorbani, Antonio A Hanson, Ilka Lorenzen-Schmidt and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Evgenia FadzeyevaThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Cassandra A A LocatelliThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Natasha A TrzaskalskiThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
My-Anh NguyenThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Megan E CapozziDuke Molecular Physiology Institute, 300 North Duke Street, Durham, NC 27701, USA.
Branka VulesevicThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Nadya M MorrowThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Peyman GhorbaniThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Antonio A HansonThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Ilka Lorenzen-SchmidtThe University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y4W7, Canada.
Mary-Anne DoyleDivision of Endocrinology & Metabolism, Department of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Richard SeymourThe University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y4W7, Canada.
Elodie M VarinLunenfeld Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Morgan D FullertonThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
Jonathan E CampbellDuke Molecular Physiology Institute, 300 North Duke Street, Durham, NC 27701, USA.
Erin E MulvihillThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON K1H 8M5, Canada.
University of Ottawa · CADuke Medical Center · USLunenfeld-Tanenbaum Research Institute · CA

Funding

ENGINEERED GLUCOSE METABOLISM IN INSULIN-SECRETING CELLSR01DK046492 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI NEWGARD, CHRISTOPHER B · 1993 to 2025
$7.8M
Engineered Glucose Metabolism in Insulin Secreting CellsR37DK046492 · NIDDK · DUKE UNIVERSITY · PI NEWGARD, CHRISTOPHER B · 2003 to 2010
$3.5M
Novel metabolic actions of GIPR01DK125353 · NIDDK · DUKE UNIVERSITY · PI CAMPBELL, JONATHAN E, D'ALESSIO, DAVID A. · 2020 to 2024
$2.1M
Mechanisms of insulin secretion mediated by alpha cellsR01DK123075 · NIDDK · DUKE UNIVERSITY · PI CAMPBELL, JONATHAN E · 2019 to 2023
$1.9M
Glucagon and insulin act cooperatively in the regulation of prandial hepatic glycogen metabolismK01DK129417 · NIDDK · UNIVERSITY OF WASHINGTON · PI CAPOZZI, MEGAN · 2021 to 2025
$679k
NIDDK NIH HHS K01 DK129417NIDDK NIH HHS R01 DK046492NIDDK NIH HHS R01 DK123075NIDDK NIH HHS R01 DK125353NIDDK NIH HHS R37 DK046492
6 · The paper itself

Abstract

Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the loss of DPP4 in endothelial cells (ECs), pointing to the contribution of non-EC types. The importance of intra-islet signaling mediated by α to β cell communication is becoming increasingly clear; thus, our objective was to determine if β cell DPP4 regulates insulin secretion and glucose tolerance in HFD-fed mice by regulating the local concentrations of insulinotropic peptides. Using β cell double incretin receptor knockout mice, β cell- and pancreas-specific

Indexed as

Biological sciencesCell biologyMolecular biologyPhysiology

Identifiers

PMID37216093
PMCPMC10192926
OpenAlexW4367043185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.