Evidence map›Paper›PMID 37215719›Full record

ArticleFrontiers in medicine2023

Skin infiltrating T-cell profile of drug reaction with eosinophilia and systemic symptoms (DRESS) reactions among HIV-infected patients.

Tafadzwa Chimbetete, Phuti Choshi, Sarah Pedretti, Mireille Porter, Riyaadh Roberts, Rannakoe Lehloenya, Jonathan Peter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tafadzwa ChimbeteteDivision of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Phuti ChoshiDivision of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Sarah PedrettiAllergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
Mireille PorterDivision of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Riyaadh RobertsDivision of Anatomical Pathology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Rannakoe LehloenyaDivision of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Jonathan PeterDivision of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Drug Reaction with Eosinophilia Systemic Symptoms (DRESS) is more common in persons living with HIV (PLHIV), and first-line anti-TB drugs (FLTDs) and cotrimoxazole are the commonest offending drugs. Limited data is available on the skin infiltrating T-cell profile among DRESS patients with systemic CD4 T-cell depletion associated with HIV. Materials and methods: HIV cases with validated DRESS phenotypes (possible, probable, or definite) and confirmed reactions to either one or multiple FLTDs and/or cotrimoxazole were chosen ( Results: Skin infiltrating T-cells were mainly found in the dermis. Dermal and epidermal CD4+ T-cells (and CD4+/CD8+ ratios) were lower in HIV-positive vs. negative DRESS; Conclusion: DRESS, irrespective of HIV status, was associated with an increased skin infiltration of CD8+ T-cells, while CD4+ T-cells were lower in HIV-positive DRESS compared to HIV-negative DRESS skin. While inter-individual variation was high, the frequency of dermal CD4+FoxP3+ T-cells was higher in HIV-positive DRESS cases reacting to more than one drug. Further research is warranted to understand the clinical impact of these changes.

Indexed as

drug reaction with eosinophilia and systemic symptomsfirst-line tuberculosis drughuman immunodeficiency virusimmunohistochemistrysevere cutaneous adverse reactionT-cell

Identifiers

PMID37215719
PMCPMC10196146
OpenAlexW4377564608

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.