Evidence map›Paper›PMID 37215637›Full record

ArticleNeurophotonics2023

Pupil engineering for extended depth-of-field imaging in a fluorescence miniscope.

Joseph Greene, Yujia Xue, Jeffrey Alido, Alex Matlock, Guorong Hu, Kivilcim Kiliç, Ian Davison, Lei Tian

Abstract read
In one paragraph

Article in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Dual-Channel Event Microscopy for Ultrafast Biological Imaging.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph GreeneBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.ORCID https://orcid.org/0000-0002-7825-4030
Yujia XueBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.
Jeffrey AlidoBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.
Alex MatlockBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.
Guorong HuBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.
Kivilcim KiliçBoston University, Department of Biomedical Engineering, Boston, Massachusetts, United States.ORCID https://orcid.org/0000-0001-7248-8728
Ian DavisonBoston University, Neurophotonics Center, Boston, Massachusetts, United States.
Lei TianBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.ORCID https://orcid.org/0000-0002-1316-4456

Funding

Computational Miniature Mesoscope for Cortex-wide, Cellular resolution Ca2+ Imaging in Freely Behaving MiceR01NS126596 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Lei Tian · 2022 to 2026
$2.0M
NINDS NIH HHS R01 NS126596
6 · The paper itself

Abstract

Significance: Fluorescence head-mounted microscopes, i.e., miniscopes, have emerged as powerful tools to analyze Aim: We present extended depth-of-field (EDoF) miniscope, which integrates an optimized thin and lightweight binary diffractive optical element (DOE) onto the GRIN lens of a miniscope to extend the DoF by Approach: We use a genetic algorithm that considers the GRIN lens' aberration and intensity loss from scattering in a Fourier optics-forward model to optimize a DOE and manufacture the DOE through single-step photolithography. We integrate the DOE into EDoF-Miniscope with a lateral accuracy of Results: We characterize the performance of EDoF-Miniscope across 5- and Conclusions: Built from off-the-shelf components and augmented by a customizable DOE, we expect that this low-cost EDoF-Miniscope may find utility in a wide range of neural recording applications.

Indexed as

computational imagingextended depth-of-fieldfluorescence microscopyminiscope

Identifiers

PMID37215637
PMCPMC10197144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.