ReviewNeurobiology of language (Cambridge, Mass.)2020
A Review on Treatment-Related Brain Changes in Aphasia.
Review in Neurobiology of language (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Rehabilitation interventions for Wernicke's aphasia and related fluent aphasia: A systematic review of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Predicting Outcomes of Language Rehabilitation: Prognostic Factors for Immediate and Long-Term Outcomes After Aphasia Therapy.Journal of speech, language, and hearing research : JSLHR · 2023Trial
- Naming practice effects and inconsistencies relate to treatment outcome in people with aphasia.Neuropsychologia · 2025Article
- Promoting Augmentative and Alternative Communication-Induced Language Recovery in Chronic Aphasia (PAIL-RcA): Theoretical Construct, Method, Protocol, and Treatment Resources.American journal of speech-language pathology · 2025Article
- EEG reveals brain network alterations in chronic aphasia during natural speech listening.Scientific reports · 2025Article
- Determinants of Multilevel Discourse Outcomes in Anomia Treatment for Aphasia.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Exploring neural tracking of acoustic and linguistic speech representations in individuals with post-stroke aphasia.Human brain mapping · 2024Article
- Disentangling neuroplasticity mechanisms in post-stroke language recovery.Brain and language · 2024Review
- Therapies and Challenges in the Post-Stroke Aphasia Rehabilitation Arena: Current and Future Prospects.Medicina (Kaunas, Lithuania) · 2023Review
- A Weak Shadow of Early Life Language Processing Persists in the Right Hemisphere of the Mature Brain.Neurobiology of language (Cambridge, Mass.) · 2022Article
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
- Plasticity of the language system in children and adults.Handbook of clinical neurology · 2022Review
- Changes in the language system as amyloid-β accumulates.Brain : a journal of neurology · 2021Article
- Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues.Brain sciences · 2021Article
- Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy.Brain sciences · 2021Article
- Neuroplasticity in post-stroke aphasia: A systematic review and meta-analysis of functional imaging studies of reorganization of language processing.Neurobiology of language (Cambridge, Mass.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Numerous studies have investigated brain changes associated with interventions targeting a range of language problems in patients with aphasia. We strive to integrate the results of these studies to examine (1) whether the focus of the intervention (i.e., phonology, semantics, orthography, syntax, or rhythmic-melodic) determines in which brain regions changes occur; and (2a) whether the most consistent changes occur within the language network or outside, and (2b) whether these are related to individual differences in language outcomes. The results of 32 studies with 204 unique patients were considered. Concerning (1), the location of treatment-related changes does not clearly depend on the type of language processing targeted. However, there is some support that rhythmic-melodic training has more impact on the right hemisphere than linguistic training. Concerning (2), we observed that language recovery is not only associated with changes in traditional language-related structures in the left hemisphere and homolog regions in the right hemisphere, but also with more medial and subcortical changes (e.g., precuneus and basal ganglia). Although it is difficult to draw strong conclusions, because there is a lack of systematic large-scale studies on this topic, this review highlights the need for an integrated approach to investigate how language interventions impact on the brain. Future studies need to focus on larger samples preserving subject-specific information (e.g., lesion effects) to cope with the inherent heterogeneity of stroke-induced aphasia. In addition, recovery-related changes in whole-brain connectivity patterns need more investigation to provide a comprehensive neural account of treatment-related brain plasticity and language recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.