Evidence map›Paper›PMID 37215541›Full record

ArticleFrontiers in cardiovascular medicine2023

Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis.

Bram W van Os, Pascal J H Kusters, Myrthe den Toom, Linda Beckers, Claudia M van Tiel, Winnie G Vos, Elize de Jong, Arnd Kieser, Cindy van Roomen, Christoph J Binder and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Bram W van OsDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Pascal J H KustersDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Myrthe den ToomDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Linda BeckersDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Claudia M van TielDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Winnie G VosDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Elize de JongDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Arnd KieserResearch Unit Signaling and Translation, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Cindy van RoomenDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Christoph J BinderDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Myrthe E ReicheDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Menno P de WintherDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Laura A BosmansDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Esther LutgensDepartment of Medical Biochemistry, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
University of Amsterdam · NLAmsterdam University Medical Centers · NLHelmholtz Zentrum München · DEMayo Clinic in Arizona · USMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atherosclerosis is the underlying cause of many cardiovascular diseases, such as myocardial infarction or stroke. B cells, and their production of pro- and anti-atherogenic antibodies, play an important role in atherosclerosis. In B cells, TRAF2 and NCK-interacting Kinase (TNIK), a germinal center kinase, was shown to bind to TNF-receptor associated factor 6 (TRAF6), and to be involved in JNK and NF-κB signaling in human B cells, a pathway associated with antibody production. Objective: We here investigate the role of TNIK-deficient B cells in atherosclerosis. Results: Conclusion: We here conclude that in hyperlipidemic

Indexed as

atherosclerosisB cellsIgAsignalingTNIK

Identifiers

PMID37215541
PMCPMC10196212
OpenAlexW4377563864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.