Evidence map›Paper›PMID 37215382›Full record

ArticleScientific African2021

Ligand-protein interactions of plant-isolated (9z,12z)-octadeca-9,12-dienoic acid with Β-ketoacyl-Acp synthase (KasA) in potential anti-tubercular drug designing.

Andrew G Mtewa, Jonathan T Bvunzawabaya, Kennedy J Ngwira, Fanuel Lampiao, Reuben Maghembe, Hedmon Okella, Anke Weisheit, Casim U Tolo, Patrick E Ogwang, Duncan C Sesaazi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific African, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Unlocking the anti-diabetic potential ofFood science & nutrition · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew G MtewaChemistry Section, Department of Applied Studies, Institute of Technology, Malawi University of Science and Technology, Malawi.
Jonathan T BvunzawabayaDepartment of Biomedical Sciences, Kamuzu University of Health Sciences, Blantyre, Malawi.
Kennedy J NgwiraSchool of Chemistry, Institute of Molecular Science, University of Witwatersrand, South Africa.
Fanuel LampiaoDepartment of Biomedical Sciences, Kamuzu University of Health Sciences, Blantyre, Malawi.
Reuben MaghembeBiotechnology Section, Centre for Chemistry and Chemical Engineering, Lund University, Lund, Sweden.
Hedmon OkellaPharmbiotechnology and Traditional Medicine Centre (PHARMBIOTRAC), Mbarara University of Science and Technology, Mbarara, Uganda.
Anke WeisheitPharmbiotechnology and Traditional Medicine Centre (PHARMBIOTRAC), Mbarara University of Science and Technology, Mbarara, Uganda.
Casim U ToloPharmbiotechnology and Traditional Medicine Centre (PHARMBIOTRAC), Mbarara University of Science and Technology, Mbarara, Uganda.
Patrick E OgwangPharmbiotechnology and Traditional Medicine Centre (PHARMBIOTRAC), Mbarara University of Science and Technology, Mbarara, Uganda.
Duncan C SesaaziPharmbiotechnology and Traditional Medicine Centre (PHARMBIOTRAC), Mbarara University of Science and Technology, Mbarara, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium tuberculosis remains one of the world's contributors to mortality. With the emergence of SARS-CoV-2 coinfections, patients with TB are predisposed to being more heavily weighed down by COVID-19 disease and its opportunistic coinfections. The severity of the disease coupled with drug resistance on the currently used drugs warrants for the search for alternative remedies from synthetic agents, semisynthetics and natural products that include plants. Africa is rich in plant diversity with a promise as sources of drug agents, one of which is

Indexed as

Computational chemistryDrug designDrug developmentDrug-protein interactionsKasA inhibitorLigand efficiencyMalawiMedicinal ChemistryM. tuberculosisβ-ketoacyl-ACP synthase

Identifiers

PMID37215382
PMCPMC10190923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.